2019/10/18 – Research Engineer Position (2 years)

France Life Imaging; Dijon; Sur place; EUR 35 000 - 50 000; Plein temps

Résumé du poste

L'Institut de Chimie Moléculaire de l’Université de Bourgogne recrute un candidat motivé pour concevoir et caractériser des conjugats basés sur des protéines ou peptides pour l'imagerie et la thérapie. Ce poste exige une forte expertise en chimie organique et une expérience en bioconjugaison, tout en offrant des interactions avec un cluster local d'imagerie. Le candidat travaillera sur des projets stimulants et contribuera activement à l'objectif de livrer des conjugats parfaitement définis à nos partenaires académiques et industriels.

Qualifications

• Expérience avérée en chimie organique et marquage protéique.
• Capacité à exécuter des tâches techniques de manière indépendante.
• Organisé(e) et capable de gérer plusieurs tâches.

Responsabilités

• Contribuer à divers programmes de R&D.
• Synthetiser des bioconjugats et développer des méthodes analytiques.
• Préparer des documents techniques et rapports d'état de projet.

Connaissances

Chimie organique

Analyse de données de chromatographie

Développement de méthodes

Communication écrite et orale

Travail collaboratif

Description du poste

Type de structure : The Institut de Chimie Moléculaire de l’Université de Bourgogne (ICMUB), in Dijon is involved in the development of innovating tools for medical imaging techniques such as nuclear imaging (PET/SPECT) or fluorescence imaging. The group is specialized in the design of new imaging probes, such as chelators (i.e. DOTA-like compounds), fluorophores, as well as their immobilization on biological vectors (peptides, antibodies, ...) through innovative bioconjugation chemistry.

Contexte et mission : In the frame of the MULTIMOD program supported by the Regional Council and the European Union, ICMUB is seeking a highly motivated candidate with strong chemistry and bioconjugation background to design, prepare and characterize protein or peptide-based conjugates for imaging/therapy purposes. The selected candidate will have the opportunity to closely interact with the local imaging cluster and the preclinical imaging platform members. He/she will contribute to the team’s mission of delivering in time, fully defined conjugates to our academic/industrial partners.

The successful candidate will have the following responsibilities:
- Involvement in various R&D and public/private programs
- Synthesis of bioconjugates, by modification of home-made proteins/peptides or coming from our partners
- Development and implementation of robust analytical methods to fully characterize antibody-based conjugates
- Synthesis of specific molecular probes, in collaboration with researchers involved in technology transfer programs
- Preparation of technical documents, summary reports and regular updates on project status
- Participation to valorization actions.

Starting date: Asap

Compétences requises : Proven track record in organic chemistry and protein labelling - Strong experience with chromatography and mass spectrometry data analysis and method development - Ability to execute technical tasks independently to achieve projects goals on an established timeline and to work in a collaborative environment - Highly organized and able to manage multiple tasks - Excellent written and oral communication skills, adaptability. Preferred but not required: - Experience in radiochemistry and molecular imaging

Contact : Prof Franck Denat, [e-mail]