2016/08/31 PhD student in protease imaging by Dynamic Nuclear Polarization, Bordeaux

France Life Imaging; Bordeaux; Sur place; EUR 20 000 - 40 000; Plein temps

Résumé du poste

A research lab specializing in imaging technologies is seeking candidates for a project on in vivo proteolysis mapping. Responsibilities include enhancing imaging performance via DNP-NMR and developing MRI sequences. Ideal candidates have experience with MRI, biochemistry, and DNP-NMR techniques. This role is based in Bordeaux, France.

Qualifications

• Experience with MRI techniques.
• Knowledge of biochemistry and molecular imaging.
• Familiarity with DNP-NMR methodologies.

Responsabilités

• Enhance imaging performance through DNP-NMR developments.
• Develop MRI sequences for acquisition and reconstruction.
• Evaluate new DNP-MRI-visible nitroxide probes.

Description du poste

Overview

Contexte et mission : TITLE : In vivo proteolysis mapping using Overhauser-enhanced MRI

Proteases, tightly regulated under physiological conditions, become overexpressed in several situations. Any non-invasive tools are welcome to understand such processes in vivio, both for their fundamental features and for diagnosis of related diseases.

The project deals with molecular imaging and is at the crossroad of developmental physics, biochemistry and medicine. The work to be performed is two-fold. First, DNP-NMR (Magnetic Resonance enhanced by Dynamic Polarization) developments are still needed to enhance imaging performance (image quality and acquisition time). MRI sequence developments in acquisition and reconstruction are expected. Second, new DNP-MRI-visible nitroxide probes (developed in collaboration) shall be evaluated for their targeting of certain proteases that can occur in various diseases (cancer, inflammation). The goal is then to target in vivo abnormal proteolysis through DNP-MRI.

Contact

eric.thiaudiere[at]u-bordeaux.fr - Magnetic Resonance Center UMR 5536 CNRS – University of Bordeaux 146, rue Leo Saignat F-33076 Bordeaux Cedex
Phone [phone] Fax [phone]
http://www.rmsb.u-bordeaux2.fr/RMSB/documents/CV%20Eric%20Thiaudiere.pdf