Postdoc in the Dynamics of Protein Synthesis and RNA Decay Lab

Somma; Barcelona; On-site; EUR 45,000 - 55,000; Full time

Job summary

Somma, located in Barcelona, is offering a postdoctoral position centered on RNA biology and gene regulation. The successful candidate will develop sequencing methods to identify mRNA decay substrates, perform bioinformatic analysis, and lead international collaborations.

Candidates should have a PhD (or nearing completion) in relevant fields, alongside bioinformatics and laboratory experience. This position offers a 2-year contract with a start date flexible from October 2026, ensuring a diverse and inclusive work environment.

Qualifications

• Bioinformatics experience in the analysis of RNA sequencing data.
• Experience with common laboratory techniques in cell and molecular biology.
• PhD degree expected to complete before starting.
• Strong publication record commensurate with career stage.
• Ability to pursue research projects independently.

Responsibilities

• Develop sequencing approaches to identify PMD substrates.
• Perform bioinformatic data analysis and visualization.
• Identify and characterize PMD candidate substrates.
• Participate in lab meetings and contribute to scientific curiosity.

Skills

Bioinformatics experience

Laboratory techniques in cell and molecular biology

Publication record

Curiosity and critical thinking

Strong analytical skills

Education

PhD in cell/molecular biology, bioinformatics, or related field

Tools

R

Python

High-performance computing

MS Office

Job description

Overview

The Höpfler lab at the Institute for Genomic Regulation (CRG) is offering a postdoctoral position focused on RNA biology and gene regulation. The role involves leading a project to develop sequencing methods that identify messenger RNA (mRNA) decay substrates and to decipher the mechanisms of degradation.

Responsibilities

• Develop sequencing approaches to identify peptide-mediated mRNA decay (PMD) substrates
• Perform bioinformatic data analysis and visualization of sequencing datasets
• Identify and mechanistically characterize PMD candidate substrates
• Present data at international conferences and prepare manuscripts
• Lead and manage international collaborations
• Actively participate in lab meetings and contribute to a culture of technical excellence and scientific curiosity

Qualifications

We are particularly interested in candidates with a hybrid wet‑lab and bioinformatics background who have a track record in RNA biology or gene regulation.

Must Have

• Bioinformatics experience in the analysis of (RNA) sequencing data
• Experience with common laboratory techniques in cell and molecular biology
• PhD degree (or expected to complete the degree before starting) in cell/molecular biology, bioinformatics, or a related field
• Strong publication record commensurate with career stage
• Ability to pursue research projects independently

Desirable

• Experience with massively parallel reporter assays (MPRAs)
• Experience exploring mRNA turnover on a transcriptome‑wide scale
• Background in RNA biology, translational control, or related areas

Languages

• Fluency in written and spoken English

Computer Skills

• Proficiency with data analysis software (R, Python)
• Experience using high‑performance computing clusters
• Advanced MS Office experience

Competences

• Curiosity and critical thinking
• Rigor, organization, and autonomy
• Strong analytical, interpersonal, and communication skills

Offer – Working Conditions

• Contract duration: Technical and scientific activities contract (estimated duration 2 years)
• Estimated annual gross salary: Salary will be commensurate with qualifications and consistent with our pay scales
• Target start date: from October 2026 (flexible)

EEO Statement

We offer and promote a diverse and inclusive environment and welcome applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation or gender identity.

The CRG is committed to reconciling work and family life of its employees and offers extended vacation periods and the possibility to benefit from flexible working hours.

Application Deadline

The position will remain open until it is covered.

Contact

Markus Höpfler [e-mail] Additional information can be found on the lab website: https://www.crg.eu/en/programmes-groups/hopfler-lab