System Manager for Drug Safety in Global IT

Ascendis Pharma; Hellerup; On-site; DKK 900,000 - 1,200,000; Full time

Job summary

Ascendis Pharma, headquartered in Hellerup, Denmark, seeks a System Manager to own the technical solutions for Drug Safety AE intake and signal detection. You will be the technical expert configuring and maintaining our SaaS intake and signal detection systems.

Collaborating with Automation, Integration, AI and Analytics teams, you will ensure systems are validated, inspection-ready and deliver an excellent end-user experience for Drug Safety professionals.

Qualifications

• Master’s degree or higher in engineering or a related technical field.
• Solid experience with pharma drug safety systems.
• Experience with SaaS vendor management and validation.

Responsibilities

• Be the technical expert of intake and signal detection solutions for Drug Safety.
• Translate business needs into SaaS configuration specifications.
• Implement configurations or work with vendors to implement them.
• Ensure systems are validated and inspection-ready.
• Prepare and present system documentation during audits and inspections.
• Oversee system support and act as escalation point for tickets.
• Maintain oversight over vendors and manage relationships.

Skills

Drug Safety systems

SaaS vendors

GxP processes for system management

Education

Master's degree in Engineering or equivalent

Job description

Are you a system manager with deep understanding of drug safety adverse event intake and signal detection process and data flows? Do you think holistically, act with ambition, and ensure the right functionality and system stability for drug safety?

Can you ensure great technical solutions, inspection-readiness and a great end-user experience for drug safety users?

If so, you may be our new System Manager.

Ascendis Pharma is a global biopharmaceutical company committed to making a meaningful difference in patients’ lives. Guided by our core values of Patients, Science, and Passion, we are applying our innovative TransCon® technology platform to fulfill our mission of developing new therapies that demonstrate best-in-class potential to address unmet medical needs.

At our headquarters in Hellerup, Denmark, research facilities in Heidelberg, Germany, and additional offices across Europe and the United States, we are advancing programs in our Endocrinology Rare Disease and Oncology portfolios. We also collaborate with partners on the development of TransCon-based products in other therapeutic areas and markets.

Our context

This position is based in our Global IT organization. In Global IT, we have spent the past five years building and maturing a product-driven organization. We operate with a strong focus on product management and lifecycle thinking, where long-lived teams take full ownership—from problem discovery to solution delivery and continuous improvement—ensuring we address real business needs.

Our structure combines clear leadership intent with empowered teams: each team member is supported by both a People Leader focused on development and a Functional Leader guiding strategy and delivery. We foster autonomy and self-organization to enable fast flow, clear accountability, and minimal dependencies.

Within the Drug Safety IT team, we have team members in the Palo Alto office focusing on our Argus platform and reporting. In Copenhagen our team focuses primarily on case intake and signal detection. This split aligns with the geographical distribution of our drug safety business function.

We are seeking

A passionate System Manager. You will be responsible for finding the right technical solutions for our Drug Safety teams focusing on AE intake and signal detection.

Practically speaking, you will be the technical expert in how our intake and signal detection systems are configured and maintained. All of these are SaaS solutions. When our SaaS solutions fall short, you will find ways to deliver functionality in collaboration with our Automation, Integration, AI and Analytics teams.

You will report to Ivanna Rosendal, Global Head of Digitalization, and Saman Sadhar, People Leader. You will be based in Hellerup, Denmark.

Your key responsibilities will be to

• Be the technical expert of our intake and signal detection solutions
• Translate business needs to specifications of configuration needed in our SaaS applications
• Either implement the configurations yourself, or work with the managed services provider or vendor to implement the configuration
• Ensure systems are in a validated state and are inspection-ready
• Prepare and present our systems and the related documentation during audits and inspections
• Oversee system support and act as escalation point for tickets
• Maintain operational oversight over vendors
• Facilitate end-user training and user groups
• Be visionary in improving our technical capabilities and suggest and implement improvements for automation, integration and seamless data flows
• Assist with documentation and validation of solutions
• Collaborate within and across the IT product teams when solving problems and delivering solutions

Qualifications and experience

You hold a relevant academic degree—preferably a Master’s degree, with a background as an Engineer, System Manager or an equivalent technical role.

You have solid experience with drug safety systems from a pharma context, minimum +5 years of relevant experience across complex organizations.

• Strong understanding of Drug Safety and their systems
• Experience with working with SaaS vendors
• Experience with GxP processes for system management

Key competencies

You are a strong team player, analytical, and have a can-do attitude.

You possess an entrepreneurial mindset and can thrive in an informal, open environment where innovation and change are key.

To succeed in this role, we also expect you to be good at collaborating with business in complex and ambiguous settings, handling conflicts constructively, and helping groups move forward.

What we offer

An exciting and challenging position in an entrepreneurial and international company with short decision paths. You will work with highly skilled colleagues and play a key role in shaping how Global IT delivers sustainable value to Ascendis Pharma and, ultimately, to patients.

Travel: 10-15 days per year

Office: Tuborg Boulevard 12, 2900 Hellerup

Flexibility: Some of the Drug Safety organization is located in the US, and meetings in the afternoon and evening will occur