Senior Principal Statistical Programmer

United States Digital Space LLC; Deutschland; Vor Ort; EUR 56.960 - 105.784; Vollzeit

Benefits dieser Stelle

Performance-based bonus

Diversity and inclusion initiatives

Zusammenfassung

United States Digital Space LLC is looking for a Principal/Senior Principal Statistical Programmer to lead programming strategies in clinical studies. This pivotal role will influence innovation and deliver regulatory-ready outputs with cross-functional teams.

The ideal candidate should have extensive experience in R, SAS, and Python, as well as a strong understanding of CDISC standards. The role offers a hybrid work environment.

Qualifikationen

• Extensive experience in statistical programming languages like R and SAS.
• Advanced knowledge of CDISC data structures.
• Strong communication skills for global collaboration.

Aufgaben

• Lead statistical programming for trials and coordinate programming teams.
• Ensure compliance with industry standards and regulatory requirements.
• Develop and validate datasets and outputs.

Kenntnisse

Statistical programming (R, SAS, Python)

Clinical study report preparation

Data visualization

Team leadership

Knowledge of regulatory requirements

Ausbildung

BS/MS degree in relevant field

Tools

Git

R Shiny Applications

Jobbeschreibung

Summary

Principal / Senior Principal Statistical Programmer

#LI-Hybrid

Location: London, UK Remote working can be considered

This role is based in London, UK. The company is unable to offer relocation support for this role. Please only apply if this location is accessible for you.

Step into a pivotal role where your expertise shapes the future of clinical development. As a Senior Principal Statistical Programmer, you will lead complex programming strategies across high-impact studies and programs, partnering with cross‑functional teams to deliver high‑quality, regulatory‑ready outputs. This is your opportunity to influence innovation, drive modern programming practices, and make a tangible difference in bringing life‑changing medicines to patients faster.

About the Role

Key responsibilities:

• Lead SP activities as Trial Programmer for one or multiple trial(s) or as a Lead/ Program Programmer for a program or an indication.
• May coordinate activities of internal/ external programmers. Make SP decisions and propose strategies at study, program or indication/disease level.
• May act as functional manager of associates including providing supervision and guidance to these programmers on operational/ functional expertise and processes.
• Build and maintain effective working relationship with cross‑functional teams, able to summarize and discuss status of deliverables and critical programming aspects (timelines, scope, resource plan), e.g. as SP representative in study‑ or program‑level team.
• Review eCRF, data structures, and ensure program‑level standardization for effective pooling and efficient case record tabulation (CRT) production.
• Comply with company, department and industry standards (e.g. CDISC) and processes, assess and clarify additional programming requirements, review, develop and influence programming specifications as part of the analysis plans (incl. program‑level strategies).
• Provide and implement statistical programming solutions; ensure knowledge sharing. Act as programming expert in problem‑solving aspects.
• Ensure timely and quality development and validation of datasets and outputs for clinical study reports (CSRs), regulatory submissions/interactions, safety reports, publications, post‑marketing activities or exploratory analyses (as required) in the assigned drug development studies/program. Understand Git‑based version control workflows and their role in supporting collaborative, traceable, and reproducible programming activities.
• Responsible for quality control and inspection readiness of all assigned statistical programming deliverables as well as accuracy and reliability of statistical analysis results. Establishes robust expectations and frameworks for reproducibility, documentation, and code quality across complex workflows; leads refinement of templates, standards, and governance.
• Maintain up‑to‑date advanced knowledge of statistical programming languages (e.g. R, SAS, ) as well as industry requirements (e.g. CDISC, eCTD, Define.xml), act as an expert for advanced analysis, reporting, automation and enterprise‑scale workflow optimization, and drive adoption of reusable solutions and modern approaches across studies or programs.

Essential Requirements:

• BS/MS degree in statistics, computer science, mathematics, data science, life science or equivalent relevant degree.
• Extensive experience and deep expertise in Statistical programming languages (e.g., R, SAS, or Python) to drive standardization across studies or programs and effectively adopt R packages (e.g. Tidyverse), R Shiny Applications, AI‑enabled tools etc. to support data visualization, version control (e.g. Git‑based), and reproducible workflows.
• Advanced experience in contributing to statistical analysis plans and/or constructing technical programming specifications.
• Advanced knowledge of industry standards including CDISC data structures as well as a solid understanding of the development and use of standard programs.
• Good understanding of regulatory requirements relevant to Statistical Programming (e.g. GCP, study procedures).
• Proven communications and negotiation skills, ability to work well with others globally and influence.
• Experience as Trial/Lead/Program Programmer for several studies or project‑level activities, including coordination of team of internal or external programmers on a given study/program, ability to transfer own knowledge to others.

Benefits & Rewards

At the company, we’re committed to reimagining medicine together - and rewarding the people who make it happen.

Expected Annual Base Salary Range for role: £49,140.00 – £91,260.00 Annual

The base salary offered is determined based on gender‑neutral objectives, such as relevant skills, competencies and experience in accordance with the company pay setting policy and upon joining the company will be reviewed periodically.

In addition to your base salary, you may be eligible for a performance‑based bonus depending on certain performance parameters.

Pay equity is a fundamental principle of our employment policy and reflects our commitment to create a diverse, equitable and inclusive environment that treats all employees with dignity and respect, as outlined in our Code of Ethics.

Read our brochure to learn more about our global total rewards offering:

https://www.the company.com/sites/the company_com/files/the company-life-handbook.pdf

*Note: Benefits and compensation may vary by country and are subject to local legal requirements, including provisions of collective bargaining agreements where applicable. A full overview of your compensation package, including any relevant collective bargaining agreement details applicable to your role based on your employment location and the company employer entity, will be communicated separately to you during the application process.*

Commitment to Diversity and Inclusion / EEO paragraph

The company is committed to building an outstanding, inclusive work environment and diverse teams’ representative of the patients and communities we serve.

Why the company: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.the company.com/about/strategy/people-and-culture

Read our handbook (PDF 30 MB)