PhD Position: Causal multi-omics modeling of disease biology (m/f/d)

International PhD Programme (IPP) Mainz; Deutschland; Vor Ort; EUR 45.000 - 65.000; Vollzeit

Benefits dieser Stelle

Advanced training

Fully funded position

International environment

Zusammenfassung

The International PhD Programme Mainz seeks talented scientists to join a vibrant community of researchers in Life Sciences and Computational Biology. PhD projects span from aging and DNA repair to epigenetics and neural memory, with English as the working language and fully funded positions through completion of the thesis.

As part of the Computational Systems Medicine group, candidates will develop causal multi-omics models, work with GWAS, QTLs, GTEx, and proteomics, and access large local

Qualifikationen

• Master’s degree in a quantitative field (stats, math, data science, bioinformatics, physics, engineering).
• Solid knowledge of statistics.
• Interest in machine learning.
• Experience with R and/or Python.

Aufgaben

• Develop and evaluate statistical and machine learning models.
• Publish results in peer-reviewed journals.

Kenntnisse

Knowledge of statistics

Interest in machine learning

Experience with R and/or Python

Ausbildung

Master’s degree in statistics, mathematics, data science, bioinformatics, physics, engineering, or a related quantitative field

Jobbeschreibung

Biological sciences > Biological engineering

Physics

Organisation/Company International PhD Programme (IPP) Mainz Department Institute of Molecular Biology Research Field Mathematics > Statistics Biological sciences > Biological engineering Physics Researcher Profile First Stage Researcher (R1) Positions PhD Positions Application Deadline 15 Oct 2026 - 12:00 (Europe/Berlin) Country Germany Type of Contract Temporary Job Status Full-time Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

Thinking of doing your PhD in the Life Sciences? The International PhD Programme (IPP) Mainz is offering talented scientists the chance to work on cutting edge research projects . As an IPP PhD student, you will join a community of exceptional scientists working on diverse topics ranging from how organisms age or how our DNA is repaired, to how epigenetics regulates cellular identity or neural memory.

Activities and responsibilities

The research group of Vincent ten Cate offers the following PhD project:
Many existing multi-omics methods focus on dimension reduction or joint latent representations to integrate heterogeneous molecular data, but are often less explicit about biological directionality and causal inference. This project instead builds on the structure of the central dogma, using genetic variation as an anchor for causal inference across molecular layers (genomics, transcriptomics, proteomics, and metabolomics), enabling more principled identification of disease-relevant proteins and pathways. A key additional aspect is the use of functional structure within the proteome-such as protein-protein interaction patterns, structural similarity, and data-driven embeddings derived from sequence or genetic perturbation-as prior information, complementing or extending curated pathway knowledge. This combination allows us to move beyond purely associative integration toward structure-aware, causally interpretable models of molecular disease mechanisms, with a focus on identifying proteins and pathways involved in cardiovascular disease.
PhD project: Causal multi-omics modeling of disease biology
We are seeking a PhD candidate to join our young team (Computational Systems Medicine) within the context of the BMFTR-funded DIASyM ( https://diasym.mscoresys.de/ ) project, to develop new statistical and computational methods for integrating multi-omics data to infer causal mechanisms of disease. We are a new group comprised of a molecular epidemiologist (group leader) and applied bioinformaticians, and are currently looking for a methodologist to complement our team.
The project focuses on building principled models that combine genetic association data (GWAS), molecular QTLs (eQTLs and pQTLs), (tissue-specific) transcriptomics (e.g. GTEx), and proteomics, with additional layers such as lipidomics and metabolomics where available. Access to large datasets is guaranteed, from local large cohort studies with multiomics phenotyping to external datasets like UK Biobank. The central goal of the project is to perform causal inference of disease-relevant proteins and molecular pathways. The disease area of interest is cardiovascular disease.
A possible direction for the work is the development of probabilistic graphical models that represent proteins as latent causal drivers of disease, while treating other omics layers as noisy, partially mediated observations. These models will incorporate biologically informed structure, including protein-protein interaction networks derived from data-driven sources such as protein embeddings, genetic variation (e.g. pQTLs) and experimental perturbation data, rather than relying on curated pathway databases (e.g. KEGG, Reactome) that introduce a human bias.
The successful candidate may incorporate methods that integrate:
- Mendelian randomization and genetic instruments
- Bayesian hierarchical models and Gaussian graphical models
- Multi-layer data integration across tissues and omics modalities
- Network-based regularization informed by protein structure and embeddings
- Scalable inference methods for genome-wide applications
However, own ideas on how to approach the project are highly welcomed. The project sits at the intersection of statistical genetics, systems biology, and machine learning, with strong emphasis on methodological development.

Tasks of the PhD Student

• Develop and evaluate statistical and machine learning models
• Publish results in peer-reviewed journals

Desired Qualifications

• Master’s degree in statistics, mathematics, data science, bioinformatics, physics, engineering, or a related quantitative field
• Knowledge of statistics
• Interest in machine learning
• Experience with R and/or Python

Qualification profile

Are you an ambitious scientist looking to push the boundaries of research while interacting with colleagues from multiple disciplines and cultures? Then joining the IPP is your opportunity to give your scientific career a flying start!

All you need is:

• Master or equivalent
• Interactive personality & good command of English
• 2 letters of reference

We offer

• Exciting, interdisciplinary projects in a lively international environment, with English as our working language
• Advanced training in scientific techniques and professional skills
• Access to our state-of-the-art Core Facilities and their technical expertise
• Fully funded positions with financing until the completion of your thesis
• A lively community ofmore than 200 PhD students from 44 different countries

The deadline for applications is 15 October 2026. Interviews will take place at IMB in Mainz on 18+19 January 2027.
Starting date: 1 February - 31 July 2027