Senior/Principal Medicinal Chemist – Lead Discovery

Ridgeline Discovery GmbH

Basel

On-site

CHF 120,000 - 190,000

Full time

6 days ago

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Job summary

Ridgeline Discovery GmbH in Basel is seeking an experienced medicinal chemist at Senior Scientist or Principal Scientist level to drive small-molecule drug discovery programs across the Ridgeline portfolio. You will own medicinal chemistry strategies, lead compound design, and oversee external chemistry activities with Biology, DMPK, and Data Science teams.

The role offers responsibility for project strategy, candidate nomination, and collaboration with Versant/Ridgeline portfolio companies in a

Qualifications

PhD in Medicinal Chemistry, Organic Chemistry, Chemical Biology or related discipline.
3–5 years of relevant industrial drug discovery experience.
Proven track record in rational compound design and multiparameter optimization.
Experience leading CRO chemistry activities and external partnerships.

Responsibilities

Independently develop and execute compound design strategies from hit identification through lead optimization and candidate nomination.
Direct and manage CRO chemistry teams and optimize workflows for efficient delivery.
Collaborate with Biology, DMPK, Computational Chemistry, and Data Science to interpret data and guide optimization.
Identify and implement innovative medicinal chemistry approaches and contribute to invention disclosures.
Contribute to project strategy and scientific due diligence across portfolio companies.