(Senior) Clinical Director

Roche; Basel; On-site; CHF 220,000 - 340,000; Full time

Job summary

Roche is seeking a Senior Clinical Director to join the neurology franchise and support late-stage studies, including the development of Trontinemab, an anti-amyloid antibody using brain-shuttle tech for Alzheimer\'s disease. You will shape clinical development strategy, oversee trial design and monitoring, and mentor a team of Clinical Scientists.

This role emphasizes scientific leadership, regulatory alignment, and collaboration across functions to advance Roche\'s neuroscience portfolio and

Qualifications

• MD/PhD with clinical neurology or dementia training.
• Solid clinical development experience including trial design and execution.
• Experience leading in pharmaceutical industry environments.

Responsibilities

• Develop clinical development strategy for late-stage trials (Phase II-III).
• Drive trial design, regulatory alignment, and scientific rigor.
• Provide medical monitoring, patient safety, and data quality oversight.
• Collaborate with regulatory, safety, biomarkers, biostats, and operations teams.
• Mentor and manage Clinical Scientists within the team.
• Engage external stakeholders such as advisory boards and health authorities.
• Contribute to publications and Roche neurology presence at conferences.
• Provide input to earlier-stage programs to strengthen the pipeline.

Skills

MD/PhD

Neurology

Clinical development

Leadership

Communication

Mentoring

Cross-functional collaboration

Education

MD/PhD

Neurology specialization

Job description

At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters.

The Position

The Opportunity

Our Clinical Development team has a fantastic opportunity for a Senior Clinical Director to join the neurology franchise to support late-stage clinical studies.

This position offers a unique opportunity to play a pivotal role in advancing the clinical development of Trontinemab , the first anti-amyloid antibody in trials to use brain-shuttle technology to treat Alzheimer's disease.

In this role you will:

• Provide a key role in the clinical development strategy for one or more late-stage (Phase II-III) trials in Alzheimer's disease

• Drive clinical trial design and execution, ensuring scientific rigor, ethical integrity, and clear regulatory alignment

• Provide medical monitoring for ongoing studies and ensure patient safety and data quality

• Collaborate with cross-functional teams including regulatory, clinical operations, safety, biomarkers, biostats, and early research

• Mentor and manage Clinical Scientists within the team

• Engage with external stakeholders such as advisory boards, key investigators, and health authorities

• Contribute to scientific publications and lead Roche’s presence in neurology through key conferences and community engagement

• Provide clinical input to earlier-stage programs to strengthen Roche’s neuroscience pipeline

Who You Are

You are a mission-driven medical leader who combines scientific expertise with strategic thinking. You bring:

• An MD or MD/PhD , with clinical training in neurology or dementia, preferably with deep expertise in Alzheimer's disease

• Solid clinical development experience , including leadership in trial design and execution (preferably in the pharmaceutical industry)

• A solid understanding of the drug development lifecycle , from early-phase studies to post-marketing

• A proven track record of scientific impact , demonstrated through publications, presentations, or advisory contributions

• Exceptional communication skills and the ability to influence across a matrixed, cross-functional environment

• Experience in line management

• A passion for innovation and collaborative problem-solving , always with the patient at the centre

Where pay transparency applies, details are provided based on the primary posting location. For this role, the primary location is Welwyn. If you are interested in additional locations where the role may be available, we will provide the relevant compensation details later in the hiring process.

Who we are

A healthier future drives us to innovate. Together, more than 100'000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact.

Let's build a healthier future, together.

The statements herein are intended to describe the general nature and level of work being performed by employees, and are not to be construed as an exhaustive list of responsibilities, duties, and skills required of personnel so classified. Furthermore, they do not establish a contract for employment and are subject to change at the discretion of Roche Products Ltd. At Roche Products we believe diversity drives innovation and we are committed to building a diverse and flexible working environment. All qualified applicants will receive consideration for employment without regard to race, religion or belief, sex, gender reassignment, sexual orientation, marriage and civil partnership, pregnancy and maternity, disability or age. We recognise the importance of flexible working and will review all applicants' requests with care. At Roche difference is valued and we are proud to be an equal opportunity employer where you are encouraged to bring your whole self to work.