Research Associate in In Vivo Genome Editing

University of Zurich; Zürich; Vor Ort; CHF 70.000 - 100.000; Vollzeit

Zusammenfassung

The University of Zurich seeks a skilled researcher to plan, coordinate and conduct in vivo studies in mouse models of genetic liver disease for clinical trial initiation. You will administer genome-editing therapeutics and perform animal monitoring, blood/tissue collection, necropsies, and downstream processing.

You will also perform molecular biology experiments (DNA/RNA isolation, PCR/qPCR, cloning) and document results with attention to Swiss regulations, collaborating with teams across

Qualifikationen

• Hands-on experience conducting mouse experiments is essential.
• Strong proficiency in molecular and cellular biology techniques.
• Ability to organize and conduct experiments independently and document results.

Aufgaben

• Plan, coordinate and conduct in vivo studies in mouse models of genetic liver disease for clinical trial initiation.
• Administer genome-editing therapeutics and other test substances.
• Perform animal monitoring, blood and tissue collection, necropsies, organ harvesting and downstream sample processing.
• Perform molecular and cellular biology experiments (DNA/RNA isolation, PCR/qPCR, cloning, sequencing preparation).
• Analyse, interpret and document results; maintain compliant records under Swiss animal-welfare regulations.
• Collaborate with scientists and partners across several research projects.

Kenntnisse

Mouse handling

Molecular biology

Cell culture

PCR/qPCR

Dosing/injections

Experimental design

English communication

Ausbildung

BSc or MSc in molecular biology/biotechnology/biomedicine or related field

Jobbeschreibung

The University of Zurich, Switzerland's largest university, offers a range of attractive positions in various subject areas and professional fields. With around 10,000 employees and currently 12 professional apprenticeship streams the University offers an inspiring working environment on cutting-edge research and top-class education. Put your talent and skills to work with us. Find out more about UZH as an employer!

Your responsibilities

• Plan, coordinate and conduct in vivo studies in mouse models of genetic liver disease required for the initiation of clinical trials.
• Administer genome-editing therapeutics and other test substances using relevant routes of delivery.
• Perform animal monitoring, blood and tissue collection, necropsies, organ harvesting and downstream sample processing.
• Perform molecular and cellular biology experiments, including mammalian cell culture, DNA and RNA isolation, PCR/qPCR, cloning and preparation of samples for sequencing.
• Analyse, interpret and document experimental results and contribute to the optimisation of experimental protocols.
• Maintain accurate records and ensure that all animal experiments are conducted in accordance with approved protocols and Swiss animal-welfare regulations.
• Collaborate closely with scientists, students and external project partners across several parallel research projects.

Your profile

• BSc or MSc in molecular biology, biotechnology, biomedicine, veterinary medicine, pharmaceutical sciences or a related discipline.
• Substantial hands‑on experience conducting experiments with mice is essential.
• Candidates should be confident in animal handling and in relevant experimental procedures such as dosing/injections, monitoring, blood sampling, tissue collection and necropsy.
• Strong practical experience in molecular and cellular biology (cloning, cell culture) and careful handling of biological samples.
• Experience with CRISPR genome editing, RNA therapeutics, lipid nanoparticles, viral vectors, liver biology or metabolic disease models is an advantage but not required.
• Ability to organise and conduct experiments independently, troubleshoot procedures and contribute effectively to multiple projects.
• A highly reliable, precise and collaborative working style, with strong attention to animal welfare and experimental documentation.
• Good written and spoken English.