Discovery Scientist – Neural Retina & Ocular Disease

Roche Holding AG; Basel; Vor Ort; CHF 110.000 - 160.000; Vollzeit

Zusammenfassung

Roche Holding AG sucht eine/n Discovery Scientist mit Schwerpunkt auf neuronaler Retina und retinaler Pathologie. Sie arbeiten an frühen Entdeckungsprojekten, etablieren Modelle und koordinieren pluridisziplinäre Teams, um Targets zu validieren und Therapien zu entwickeln.

Sie verfügen über eine Promotion in Biologie oder verwandten Bereichen sowie postdoktorale Erfahrung in der Augenheilkunde, idealerweise mit 2D/3D-Modellen oder Tiermodellen.

Qualifikationen

• :PhD in Biology, Neuroscience, Biochemistry or related field.
• Postdoctoral Fellowship experience in vision research or related area.
• Experience with ocular disease models and retinal pathology mechanisms.
• Hands-on experience with animal work or advanced 2D/3D models (organoids, organ-on-a-chip).
• Proven record of publications in top-tier vision journals.
• Strong English communication and collaboration skills.

Aufgaben

• Target identification, validation using in vitro/in vivo ocular disease models.
• Develop and evaluate therapeutic modalities for selected targets.
• Lead drug discovery projects from initiation to Phase II readiness.
• Collaborate with pRED teams (bioinformatics, safety, translational medicine).
• Manage external collaborations and CRO activities.
• Present findings at internal meetings and international conferences.
• Discovery Lab Management: Sicherheits- und Laborprozesse koordinieren.

Kenntnisse

Neural retina biology

Animal handling

2D/3D model systems

Cell/tissue culture

Omics technologies

Bioinformatics tools

English communication

Project leadership

Cross-functional collaboration

Ausbildung

PhD in Biology/Neuroscience/Biochemistry

Postdoctoral Fellowship in Vision Research/Neural Retina/Ophthalmology

Jobbeschreibung

Bei Roche kannst du ganz du selbst sein und wirst für deine einzigartigen Qualitäten geschätzt. Unsere Kultur fördert persönlichen Ausdruck, offenen Dialog und echte Verbindungen. Hier wirst du für das, was du bist, wertgeschätzt, akzeptiert und respektiert. Dies schafft ein Umfeld, in dem du sowohl persönlich als auch beruflich wachsen kannst. Gemeinsam wollen wir Krankheiten vorbeugen, stoppen und heilen und sicherstellen, dass jeder Zugang zur Gesundheitsversorgung hat – heute und in Zukunft. Werde Teil von Roche, wo jede Stimme zählt.

Die Position

Our Ophthalmology team in Basel focuses on discovering novel therapeutic approaches for major eye diseases, encompassing dry AMD/geographic atrophy and neovascular forms, as well as diabetic retinopathy, and other retinal vascular diseases. We are seeking a highly motivated Discovery Scientist with specialized expertise in the neural retina and retinal pathology, including processes such as inflammation, vascular dysfunction, ischemia, fibrosis, and neurodegeneration, to drive our early-stage drug discovery efforts.

The opportunity:

In this role, your key responsibilities include, but are not limited to:

• Target Identification & Validation: Utilize and establish advanced in vitro and in vivo models of ocular disease, and leverage available patient sample datasets to identify, validate, and characterize novel therapeutic drug targets.

• Therapeutic Approach Development: Identify and evaluate optimal therapeutic modalities for selected targets.

• Project Leadership: Independently lead and manage drug discovery projects from target initiation through early clinical development stages (up to Phase II readiness).

• Cross-Functional Collaboration: Partner with interdisciplinary teams across pRED (including bioinformatics, safety, and translational medicine) to advance pipeline programs.

• External Collaboration: Initiating and leading external collaboration projects to bolster internal efforts. Manage CRO activities, including project design, timelines, and quality of deliverables.

• Scientific Communication: Present research findings at internal decision-making meetings, author high-impact publications in top-tier peer-reviewed journals, and represent Roche at international scientific conferences.

• Discovery Lab Management: Support and coordinate safety, health, and environmental processes in the lab.

You who are:

• You hold a PhD in Biology, Neuroscience, Biochemistry, or a related life sciences discipline.

• You have completed a Postdoctoral Fellowship in Vision Research, Neural Retina, Ophthalmology, or a closely related field.

• You bring comprehensive knowledge of neural retina biology and the mechanisms underlying retinal disease pathogenesis, together with a proven track record of conducting experiments using models of ocular angiogenesis, fibrosis, inflammation, or neurodegeneration.

• You have direct hands-on experience in animal handling and/or ocular procedures, OR demonstrated expertise in developing novel 2D/3D model systems, such as organoids or organ-on-a-chip. You also bring experience in cell/tissue culture, -omics technologies, and/or basic bioinformatic tools.

• You demonstrate excellent organizational skills, rigorous record-keeping, exceptional oral and written English communication, and a strong collaborative mindset in a fast-paced environment.

• You bring 2–3 years of additional professional experience in academic or industry drug discovery settings, together with a proven track record of leading research projects and cross-functional project teams and a strong publication record in top-tier vision or scientific journals.

• You have an established professional network within the global ophthalmology research community.

At Roche, we aim high to deliver life-changing healthcare solutions. If you’re ready to make a meaningful impact on patients and healthcare systems worldwide, this is the place for you.

Wer wir sind

Eine gesündere Zukunft treibt uns zur Innovation an. Mehr als 100.000 Mitarbeiter weltweit arbeiten gemeinsam daran, wissenschaftliche Fortschritte zu erzielen und sicherzustellen, dass jeder Zugang zur Gesundheitsversorgung hat – heute und für zukünftige Generationen. Durch unser Engagement werden über 26 Millionen Menschen mit unseren Medikamenten behandelt und mehr als 30 Milliarden Tests mit unseren Diagnostik-Produkten durchgeführt. Wir ermutigen uns gegenseitig, neue Möglichkeiten zu erkunden, Kreativität zu fördern und hohe Ziele zu setzen, um lebensverändernde Gesundheitslösungen zu liefern.

Gemeinsam können wir eine gesündere Zukunft gestalten.

Roche ist ein Arbeitgeber, der die Chancengleichheit fördert.