Biomarker Expert Leader Ophthalmology

F. Hoffmann-La Roche AG; Basel; Vor Ort; CHF 180.000 - 240.000; Vollzeit

Zusammenfassung

Roche's Ophthalmology Biomarker team seeks a Biomarker Experimental Medicine Leader to drive translational biomarker strategies across preclinical and clinical programs. You will lead biomarker activities to quantify responses, aid patient selection, and guide drug development decisions.

Ideal candidates hold a PhD or MD with 7+ years in biomarker roles and can lead matrix teams in a global organization, bringing strong communication and strategic thinking to advance ophthalmology projects.

Qualifikationen

• PhD or MD with 7+ years in research, industry or clinical settings.
• At least 3 years biomarker work in drug development, with protein/metabolite/genetic/imaging readouts preferred.
• Able to lead cross-functional matrix teams and prioritize deliverables.

Aufgaben

• Develop end-to-end translational biomarker strategies during preclinical and clinical phases.
• Lead biomarker activities to quantify drug response and patient selection.
• Act as Matrix Leader of the BioX Expert Team.
• Collaborate with internal and external experts on biomarker studies and endpoints.

Kenntnisse

Biomarker expertise

Translational science

Cross-functional leadership

English fluency

Ausbildung

PhD or MD

Tools

Omics data interpretation

Ocular imaging

Jobbeschreibung

At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters.

The Position

In Roche’s Pharmaceutical Research and Early Development organization (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility, and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed. Roche has a strong pipeline of Ophthalmology medicines and is expanding its portfolio in retinal vascular diseases, dry age-related macular degeneration and front of the eye diseases. With global partnerships and collaborations, Roche offers ample opportunities for drug development and career growth in Ophthalmology. The Ophthalmology unit of Roche is rapidly growing and innovating and therefore offers the position of a Biomarker Experimental Medicine Leader (BEML). We are offering the opportunity to join our Ophthalmology biomarker team. Currently, we are a team of six biomarker leaders with different backgrounds in biochemistry, cell-biology, molecular biology, experimental ophthalmology and drug development that we apply to diseases like age-related macular degeneration, diabetic retinopathy, dry eye disease, and others. We are looking for a biomarker expert with strong experience in translational science that can complement our team as an individual contributor and matrix team leader.

The opportunity

In this role, you will be accountable for the development and implementation of end-to-end translational biomarker strategies during the preclinical and clinical phases of drug development programs. You will lead biomarker-related activities aimed at quantifying drug response and selecting patients for personalized healthcare, acting as Matrix Leader of the BioX (Bioanalytical, Biosample and Biomarker) Expert Team. You will assume accountability for research collaborations designed to benefit multiple programs, in line with the relevant project and disease area strategies. You will be an active member of preclinical and clinical drug development and project teams. You will provide scientific and strategic input into the overall drug and clinical development plans and ensure that biomarker-related activities are fit for purpose and support decision-making within the context of the preclinical and clinical development strategy. You will collaborate with academic, industry, internal and external experts, as well as service providers, on biomarker, experimental medicine and natural history studies to identify and evaluate disease biomarkers and novel clinical trial endpoints.

Who you are

You hold a PhD and/or MD degree and have at least 7 years of well‑documented experience in a research, industry or clinical setting. This experience should include at least 3 years of biomarker-related work in the context of drug development, preferably involving protein, metabolite, genetic, imaging or functional biomarkers. You are able to lead cross-functional matrix teams, drive team decisions and project needs, and prioritize your work to achieve both individual goals and team deliverables.

You have a good understanding of methodological and bioanalytical approaches and are able to generate, integrate and interpret preclinical, clinical and drug development data to enable proof of biology, dose selection, patient selection and safety across clinical programs. You are a proactive team player who integrates easily into a global organization. You have strong networking skills, are capable of working independently, and enjoy contributing to a collaborative environment where success is driven by the team rather than by individual heroes.

You have strong presentation and communication skills and are fluent in English. You are an innovative and strategic thinker who sees the big picture. You are goal-oriented, have a strong drive and analytical mindset, and are motivated to achieve excellence. You are also able to distill complex topics, develop solutions and articulate them clearly. Prior experience in Ophthalmology would be a valuable asset. Experience with omics data interpretation, ocular imaging or functional readouts would be an additional advantage.

At Roche, we aim high to deliver life-changing healthcare solutions. If you’re ready to make a meaningful impact on patients and healthcare systems worldwide, this is the place for you.

Where pay transparency applies, details are provided based on the primary posting location. For this role, the primary location is Basel. If you are interested in additional locations where the role may be available, we will provide the relevant compensation details later in the hiring process.

Who we are

A healthier future drives us to innovate. Together, more than 100’000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact. Let’s build a healthier future, together.

Roche is an Equal Opportunity Employer. We believe it’s urgent to deliver medical solutions right now – even as we develop innovations for the future. We are passionate about transforming patients’ lives. We are courageous in both decision and action. And we believe that good business means a better world. That is why we come to work each day. We commit ourselves to scientific rigor, unassailable ethics, and access to medical innovations for all. We do this today to build a better tomorrow. We are proud of who we are, what we do, and how we do it. We are many, working as one across functions, across companies, and across the world. We are Roche.