Biologics PK & PBPK Research Internship

F. Hoffmann-La Roche AG; Basel-Stadt; On-site; CHF 21,000 - 30,000; Full time

Job summary

Roche's internship opportunity in the tDMPK/PD section of pRED offers hands‑on experience with in vitro techniques such as high‑content imaging and CE‑SDS immunoassays. You will explore target‑mediated degradation and system stability while gaining exposure to PBPK modeling for biologics throughout drug development.

Strong English skills are essential, with German/French a plus. The six to twelve‑month internship, starting Feb 2027, emphasizes practical experimentation, data analysis, and

Qualifications

• In vitro experimental methodologies (cell culture, microscopy, high-content imaging, western blotting, ELISA) and data interpretation.
• Interest in PBPK modeling approaches for biologics during drug development.
• Fluent written and spoken English; German or French a plus.

Responsibilities

• Perform hands-on in vitro experiments to investigate system stability and target‑mediated degradation of drug candidates.
• Collaborate to construct and evaluate bottom‑up PBPK models from pre‑clinical data to forecast clinical PK.

Skills

In vitro techniques

PBPK modeling

Team collaboration

Data analysis

English communication

Education

University degree in progress or completed within the last 12 months

Fields: pharmacy, pharmacology, biochemistry or molecular biology

Tools

Microsoft Office

R Studio

GraphPad Prism

CE-SDS immunoassays

Job description

Roche's internship opportunity in the tDMPK/PD section of pRED offers hands‑on experience with in vitro techniques such as high‑content imaging and CE‑SDS immunoassays. You will explore target‑mediated degradation and system stability while gaining exposure to PBPK modeling for biologics throughout drug development.

Strong English skills are essential, with German/French a plus. The six to twelve‑month internship, starting Feb 2027, emphasizes practical experimentation, data analysis, and