Sr. Principal Scientist - Discovery Radiochemistry

Eli Lilly and Company; Ontario; On-site; CAD 80,000 - 110,000; Full time

Job summary

An established industry player is seeking a talented radiochemist to support the discovery program by developing innovative radiolabeling processes. This role offers the chance to collaborate with internal teams and external partners to supply radiolabeled compounds for groundbreaking preclinical experiments. The ideal candidate will possess a strong background in organic chemistry and radiochemistry, with the ability to thrive in a fast-paced laboratory environment. Join a team dedicated to making a difference in global healthcare through scientific discovery and innovation.

Qualifications

• 5+ years of relevant radiochemistry experience or a PhD in a related field.
• Proven ability to work independently and manage timelines effectively.

Responsibilities

• Develop radiochemistry processes and formulations for preclinical evaluation.
• Train team members and external partners on radiochemistry processes.

Skills

Radiochemistry

Analytical Testing

Project Management

Communication Skills

Education

BS/MS in Organic Chemistry

PhD in Organic Chemistry

Tools

Radio-HPLC-MS

Automated Radiosynthesizers

Job description

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

At Lilly, we serve an extraordinary purpose. For more than 140 years, we have worked tirelessly to discover medicines that make life better. These discoveries start in Lilly Research Laboratories, where our scientists work to create new medicines that will help solve our world’s greatest health challenges.

Position Summary:

The individual will be supporting the discovery program by developing both therapeutic and diagnostic radiolabeling processes and ensuring supply of materials. The individual will work collaboratively with internal team members and external partners to enable the supply of radiolabeled compounds for preclinical experiments.

Responsibilities:

• Develop radiochemistry processes and formulations.
• Develop suitable analytical testing methods to characterize research batches.
• Produce, test, and supply radiolabeled compound batches to support preclinical evaluation of radiolabeled compounds internally/externally.
• Transfer radiochemistry and testing methods to team members and external partners.
• Train internal colleagues or external partners on radiochemistry processes and associated methods. Provide onsite/remote technical support to external partners as needed.
• Prepare and deliver presentations for internal and external team meetings.
• Author applicable laboratory notebook entries, development reports, manuscripts for publication in journals and patents.
• Other duties as assigned.

Basic Requirements:

• BS/MS in organic chemistry, chemistry or a related discipline and 5+ years of relevant radiochemistry experience or PhD degree in organic chemistry, coordination/inorganic chemistry or radiochemistry.
• Proven ability to work independently with strong organization and excellent written/verbal communication skills.
• Demonstrated ability to successfully prioritize projects and manage timelines in a fast-paced environment.

Additional Preferences:

• Previous working experience in radiochemistry environment.
• Hands on experience with imaging radioisotopes (F-18, Ga-68, Cu-64, In-111, Zr-89) and/or therapeutic radioisotopes (Lu-177, Ac-225, Pb-212, Tb-161) is considered an asset.
• Experience in quality control testing of radiolabelled compounds (hands-on experience with radio-HPLC-MS, radio-ITLC) is considered an asset.
• Knowledge of environmental health and radioprotection requirements.
• Good working knowledge of multiple automated radiosynthesizer.
• Functional Knowledge of GMPs and applicable FDA, EMA, Health Canada, USP, ICH and PDA guidelines.

Physical Demands/Travel:

• Requires up to 20% of travel nationally and internationally. A valid passport and eligibility to travel into these countries are required.
• Requires ability to lift up to 30 kg.
• Requires safety shoes and other personal protective equipment at applicable work area.

Work Environment:

• This position’s work environment is in a Laboratory. Position requires to be onsite during the work week.