Senior Scientist, Stem Cell Model Engineering( Contract)

Amgen; Burnaby; On-site; CAD 115,503 - 156,269; Full time

Benefits offered by this job

Competitive and comprehensive Total Rewards Plans

Job summary

Amgen is looking for a Sr. Scientist in Burnaby to develop and innovate genetically engineered human iPSC models. The successful candidate will troubleshoot complex systems and improve workflows while ensuring data integrity.

PhD or MSc holders with relevant experience in stem cell biology and strong communication skills are encouraged to apply. The position offers a competitive salary range between $115,503 – $156,269 CAD.

Qualifications

• PhD with 2+ years postdoctoral/industry experience in relevant fields.
• Hands-on experience generating CRISPR-edited iPSC models.
• Strong scientific productivity through peer-reviewed publications.

Responsibilities

• Develop genetically defined iPSC model systems.
• Drive innovation by improving workflows.
• Communicate technical risks and readiness clearly.

Skills

Stem cell biology

Molecular biology

Experimental judgment

Collaboration skills

CRISPR technology

Education

PhD in related discipline

MSc with 5+ years

BSc with 8+ years

Job description

Sr. Scientist, Stem Cell Model Engineering

Join the Predictive Biology team as a hands‑on scientist focused on building genetically engineered human induced pluripotent stem cell (iPSC) models to support target discovery, target validation, and mechanism‑of‑action studies. You will troubleshoot complex systems, improve current workflows, and help drive the next wave of innovation in human stem cell model engineering.

Key Responsibilities

• Develop genetically defined iPSC model systems, including reporter, tagged, loss‑of‑function, disease‑relevant, inducible, or otherwise perturbable models.
• Define and interpret fit‑for‑purpose validation strategies to determine whether engineered models are suitable for downstream biological studies.
• Identify, troubleshoot, and solve technical and biological failure modes, including poor editing outcomes, clonal artifacts, expression instability, differentiation defects, and loss of engineered function.
• Drive innovation by identifying technical gaps, improving workflows, and building new capabilities in engineered human stem cell models.
• Communicate technical risks, timelines, decision points, and model readiness clearly through written and oral presentations.
• Maintain high standards for data integrity, reproducibility, documentation, and experimental rigor.

Basic Qualifications

• PhD in a related discipline with 2+ years of experience
• MSc with 5+ years of experience
• BSc with 8+ years of experience

Preferred Qualifications

• PhD with 2+ years of postdoctoral and/or industry experience in stem cell biology, molecular biology, cell engineering, genetics, developmental biology, bioengineering, or a related discipline.
• Demonstrated hands‑on experience generating CRISPR‑edited human iPSC models or other difficult‑to‑engineer human cellular model systems.
• Strong experimental judgment in genome‑engineering strategy, model design, validation requirements, and interpretation of engineered cell model data.
• Practical understanding of common failure modes in engineered iPSC models, including clonal artifacts, unintended genetic changes, expression instability, differentiation issues, and loss of engineered behavior.
• Demonstrated scientific productivity and technical credibility through peer‑reviewed publications and patents.
• Strong communication and collaboration skills and ability to work effectively as part of a multidisciplinary team.

What You Can Expect Of Us

The salary range for this position in Canada is $115,503 – $156,269 CAD. In addition to the base salary, Amgen offers competitive and comprehensive Total Rewards Plans that are aligned with local industry standards.

Equal Opportunity Statement

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.