Senior Scientist – Directed Evolution & Protein Design, Large Molecule Discovery

Amgen; Burnaby; On-site; CAD 117,000 - 141,000; Full time

Job summary

A leading biotechnology company in Burnaby seeks a Senior Scientist to lead enzyme engineering projects and innovate in protein design. The successful candidate will have a Ph.D. and experience in directed molecular evolution. Join us to make a lasting impact on patients' lives while developing your career in a collaborative environment.

Benefits

Competitive salary

Comprehensive benefits

Collaborative culture

Qualifications

• Ph.D. with 1-3 years of industrial or postdoc experience.
• Strong publication record in relevant fields.
• Self-driven and able to tackle high impact problems.

Responsibilities

• Lead enzyme engineering efforts for novel therapeutics.
• Develop computational approaches for predicting immunogenicity.
• Enhance generative AI capabilities for protein design.

Skills

Directed molecular evolution

High-throughput screening

Enzyme library design

Independent work

Collaboration

Creativity

Education

Ph.D. in Biochemistry or related field

Job description

Career Category Scientific Job Description Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Senior Scientist – Directed Evolution & Protein Design, Large Molecule Discovery What you will do

Let’s do this. Let’s change the world.

We have an opening for a Senior Scientist on our Discovery Protein Science team that is located at our Amgen British Columbia site. Our team supports Amgen’s therapeutic discovery pipeline through innovations in protein design and generation while working on diverse and complex biological molecules. This role will specifically involve leading our enzyme engineering efforts around discovering novel therapeutics for rare and genetic diseases. Such efforts will entail the use of directed molecular evolution and rational design, including computational approaches. As part of this effort, quantitative structure-function relationships will also be developed and used to enhance our generative AI capabilities for enzyme and protein design. Furthermore, a major focus of this role will include the implementation of computational design to predict and prevent the immunogenicity of enzymes and other proteins. By contributing to these areas, the successful candidate will fill an important gap at the interface between protein design, enzyme engineering, target discovery, and experimental immunology.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients.

Basic Qualifications:

• Ph.D. in Biochemistry, Chemistry, Chemical and/or Biological Engineering, Biophysics or a related field with 1-3 years industrial or postdoc experience with strong publication record
• Experience in directed molecular evolution and high-throughput screening and characterization
• Experience in enzyme library design and in silico protein design
• Ability to work independently while also collaborating with cross-functional teams
• Strong organizational, interpersonal, and communication skills
• Self-driven, creativity, and willingness to work on difficult and high impact problems
• Commitment to diversity and equity while creating a welcoming and inclusive work environment

Preferred Qualifications:

• Understanding of immune biology and immunogenicity
• Strong background in structural biology and biophysics
• Application of AI/ML models to protein design and engineering

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The salary range for this position in Canada is $117,814 - 140,059 CAD.

Amgen is proud to have been recognized as one of LinkedIn Top 25 Companies in Canada for career growth. Click HERE for more details. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

In addition to the base salary, Amgen offers competitive and comprehensive Total Rewards Plans that are aligned with local industry standards.

Apply now and make a lasting impact with the Amgen team. careers.amgen.com

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

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