Senior Analytical Development Scientist - HPLC Specialist

Placements24; Kimberley; Hybrid; CAD 84,000 - 127,000; Full time

Benefits offered by this job

Health insurance

Retirement plan

Paid time off

Professional development

Job summary

Placements24 is seeking a Senior Analytical Development Scientist with a focus on HPLC to join a leading pharmaceutical research organization in Kimberley, ZA. The role centers on developing, validating, and implementing robust analytical methods for drug substances and products throughout the development lifecycle.

You will mentor junior scientists, ensure GLP and GMP compliance, conduct stability studies, and contribute to regulatory submissions while collaborating with formulation, process

Qualifications

• PhD or MSc in Analytical Chemistry, Pharmaceutical Sciences, or related field.
• Minimum 5 years in analytical method development/validation within pharma.
• Hands-on HPLC/UPLC including method development and troubleshooting.
• Proficiency in LC-MS desirable.
• Knowledge of ICH guidelines and regulatory expectations.
• Experience with data analysis software and LIMS.

Responsibilities

• Develop and validate analytical methods for identification, quantification, and purity using HPLC/UPLC/LC-MS.
• Optimize chromatographic conditions for separation and sensitivity.
• Troubleshoot analytical methods and instrumentation.
• Conduct stability studies and assess shelf-life and degradation pathways.
• Prepare method validation reports for regulatory submissions.
• Collaborate with formulation scientists, process chemists, and quality control teams.
• Stay current with advances in analytical chemistry and regulatory expectations.
• Mentor junior analytical scientists and provide technical guidance.
• Ensure GLP and GMP compliance.

Skills

HPLC method development

UPLC

LC-MS

Regulatory compliance

Data analysis

GLP GMP

Education

PhD or MSc in Analytical Chemistry

Tools

LC-MS instrumentation

LIMS

Job description

About the Role Our client, a prominent pharmaceutical research organization, is seeking a Senior Analytical Development Scientist with a specialization in High-Performance Liquid Chromatography (HPLC) to join their team. This role, based in Kimberley, Northern Cape, ZA, is essential for developing, validating, and implementing robust analytical methods for the characterization of pharmaceutical products and intermediates. You will play a key role in ensuring the quality and integrity of our products throughout the development lifecycle. The hybrid work arrangement provides flexibility while maintaining critical laboratory presence in Kimberley, Northern Cape, ZA.

Key Responsibilities

• Develop and validate analytical methods for the identification, quantification, and purity assessment of drug substances and drug products using HPLC and related techniques (e.g., UPLC, LC-MS).
• Optimize chromatographic conditions to achieve desired separation and sensitivity.
• Troubleshoot analytical methods and instrumentation, resolving technical issues promptly.
• Conduct stability studies and analyze data to assess product shelf-life and degradation pathways.
• Prepare comprehensive analytical method validation reports and documentation for regulatory submissions.
• Collaborate with formulation scientists, process chemists, and quality control teams.
• Stay current with advancements in analytical chemistry, chromatography, and regulatory expectations.
• Mentor junior analytical scientists and provide technical guidance.
• Ensure compliance with Good Laboratory Practices (GLP) and Good Manufacturing Practices (GMP).

Requirements

• Ph.D. or Master's degree in Analytical Chemistry, Pharmaceutical Sciences, or a related field.
• Minimum of 5 years of experience in analytical method development and validation within the pharmaceutical industry.
• Extensive hands-on experience with HPLC and UPLC systems, including method development, optimization, and troubleshooting.
• Proficiency in LC-MS is highly desirable.
• Strong understanding of pharmaceutical product development, quality control, and regulatory requirements (e.g., ICH guidelines).
• Experience with data analysis software and LIMS.
• Excellent problem-solving, analytical, and communication skills.
• Ability to work independently and as part of a collaborative team in Kimberley, Northern Cape, ZA.
• Detail-oriented with strong organizational skills.

Benefits

Our client offers a competitive salary, comprehensive benefits package including health insurance, retirement contributions, and generous paid time off. Employees have access to state-of-the-art analytical instrumentation and a supportive research environment in Kimberley, Northern Cape, ZA. The company invests in professional development, providing opportunities for training and conference participation. Join a dedicated team committed to ensuring the highest standards of pharmaceutical quality.