Scientist, Radiopharmaceutical Development

Working with Us
Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

About RayzeBio
RayzeBio, a Bristol Myers Squibb company, is a dynamic biotechnology company headquartered in San Diego, CA. The company is focused on improving survival of people with cancer by harnessing the power of targeted radioisotopes. RayzeBio is developing innovative drugs against targets of solid tumors. Led by a successful and experienced entrepreneurial team, RayzeBio aims to be the global leader in radiopharmaceuticals.

Position Overview
The Radiopharmaceutical Development Scientist will be responsible for taking a lead technical role in both radiochemical and analytical methods for the drug product programs at RayzeBio. This role will help to drive the CMC radiopharmaceutical process development for RayzeBio's novel pipeline. The radiopharmaceutical development scientist will assist with the CMC development plan and IND enabling activities, leading to clinical manufacturing of the drug product. In this function, the candidate will be translating pre-clinical/research methods and data to develop compliant processes and clinical drug product specifications and manage the execution of CMC studies.

Responsibilities:

• Design and execute radiochemistry and radiolabeling experiments to determine suitable process flow, process conditions, materials selection, acceptable range, etc. to enable formulation lock.
• Provide technical expertise and leadership on radiopharmaceutical production processes and quality control/analytical methodologies.
• Develop and support the technical transfer package of clinical drug products to the Indianapolis manufacturing facility and CDMO partners.
• Support the set-up and ongoing function of the radiochemistry laboratory to support translational development from pre-clinical to clinical activities.
• Collaborate with interdisciplinary teams of discovery scientists and researchers as well as external partners (such as CDMOs) to address complex scientific questions and pursue collaborative research projects, if applicable.
• Handle radioactive materials safely and in accordance with established internal procedures and regulatory guidelines. Maintain a safety-first mindset via thorough understanding of radiation safety procedures, including shielding, monitoring, and waste disposal, to ensure compliance with safety standards.
• Operate specialized laboratory equipment and instrumentation used in radiochemical analysis and experimentation, such as HPLCs, TLCs, gamma counters, and scintillation detectors. Provide technical expertise to troubleshoot potential equipment issues and perform routine maintenance as needed.
• Analyze experimental data, interpret results, and draw conclusions based on scientific principles and theoretical models. Document findings in technical reports and presentations for internal and external review and meetings.
• Manage third party vendors in support of analytical and laboratory equipment.
• Draft documentation including but not limited to relevant CMC sections in regulatory packages, SOPs, and development reports.
• Less than 5% of travel is required.

Basic Qualifications:

• BS Degree with 5+ years of industry experience working with radioactive materials or MS with 3+ years of industry experience working with radioactive materials or PhD with 1+ years of industry experience working with radioactive materials.
• Hands-on experience with commercially available radiopharmaceutical manufacturing and quality control equipment systems, including automation of radiochemistry synthesis, for example (but not limited to) radioHPLC, radioTLC, gamma counter, dose calibrator, hot cell manipulators, gamma spectroscopy, etc.
• Experience in radiochemical synthesis, purification, and analytical techniques.
• Experience working with a variety of radioactive materials for both diagnostic and therapeutic use.
• Working knowledge of federal and state regulatory requirements and safety protocols governing the handling and use of radioactive materials.

Preferred Qualifications:

• Experience developing stable radiopharmaceutical clinical formulations to achieve specific qualities, such as shelf-life and radiochemical purity.

Skills and Knowledge:

• Excellent professional ethics, integrity, and ability to maintain confidential information.
• Excellent written and verbal communication skills; strong communicator and influencer within all levels of the organization, including executive leadership.
• Team-oriented, progressive thinker who enjoys participating in an innovative and creative work environment.
• Ability to operate in a fast-paced, multi-disciplinary industrial environment.

Physical Demands:
While performing the duties of this job, the employee is regularly required to sit, reach with hands and arms, and talk or hear. The employee must occasionally lift and/or move up to 30 pounds. Specific vision abilities required by this job include close vision and distance vision.

This position requires working in a laboratory environment, and protective clothing, gloves, and safety glasses are required while working in a laboratory environment with radioactive materials.

If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as Transforming patients' lives through science, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion, and integrity bring out the highest potential of each of our colleagues.