Scientist I, Dx Radiochemistry CMC

Alpha-9 Oncology; Vancouver; On-site; CAD 75,000 - 95,000; Full time

Job summary

Alpha-9 Oncology is seeking a highly motivated Scientist I to contribute to the development of targeted radiopharmaceuticals in Vancouver. This role involves optimizing radiolabeling processes and analytical testing while supporting technology transfers. You will collaborate with multidisciplinary teams and ensure compliance with regulations in a dynamic environment focused on career growth.

Benefits

Competitive salary

Bonus and equity options

20 vacation days and 5 sick days

Technology allowance

Commuter reimbursement

Generous retirement savings plans with employer matching

Extended health benefits

Paid holidays

Qualifications

• PhD in a related field with 1+ years or MSc with 4+ years in process development.
• Experience in developing automated radiolabeling methods for GMP manufacturing.
• Hands-on experience with isotopes and analytical techniques relevant to radiopharmaceuticals.

Responsibilities

• Conduct radiochemistry experiments and develop radiolabeling processes.
• Collaborate across teams to drive project goals and timelines.
• Develop analytical methods and ensure compliance with safety regulations.

Skills

Radiochemistry

Analytical techniques

Problem-solving

Project management

Communication

Education

Ph.D. in Radiochemistry, Chemistry, Analytical Chemistry, Nuclear Engineering

M.Sc. with 4+ years in relevant field

Job description

Alpha-9 Oncology is seeking a highly motivated Scientist I, with a strong background in radiolabeling process development and analytical method development to join our growing organization. In this role, you will contribute to the development and delivery of targeted peptide- and small molecule-based radiopharmaceuticals for both preclinical and clinical applications. You will support radiolabeling process optimization, analytical testing, and technology transfer to CDMO partners. You'll have the chance to make a real impact on our mission while enjoying a dynamic work environment that fosters learning and career progression..

Reporting to the Director, Dx Radiopharmaceutical Development, you will play a key role in shapingour radiopharmaceutical development program, enabling you to see the direct results of your contributions and grow alongside a passionate team. This role is based in ourVancouver office.

How You'll Contribute

• Conduct radiochemistry experiments and develop manual or automated radiolabeling processes to deliver robust clinical formulations that meet diagnostic product profiles.
• Design and execute experiments, critically analyze data, troubleshoot technical issues, and perform follow-up studies to support process development and problem-solving.
• Collaborate across multidisciplinary teams and represent radiochemistry in project discussions to drive development goals, timelines, and decision-making.
• Develop analytical methods, QC procedures, and technology transfer packages to support CDMO/CRO partnerships and ensure process scalability.
• Drive continuous improvement initiatives in both process optimization and the safe handling of radioactive materials in accordance with Nuclear Safety Regulations (e.g., CNSC).
• Participate in investigations of out-of-specification results or synthesis failures and contribute to root cause analysis and knowledge building.
• Author, revise, and review technical documentation, including SOPs, development reports, test methods, protocols, batch records, specifications, and regulatory submissions.
• Ensure compliance with Health & Safety policies, radiation safety regulations, and applicable regulatory guidelines, including ICH, GMP, and international pharmacopeias.

The Skills you Bring

• PhD in Radiochemistry, Chemistry, Analytical Chemistry, Nuclear Engineering, or a related field with 1+ years of experience, or MSc with 4+ years, in radiopharmaceutical process development, formulation, manufacturing, or tech transfer.
• Hands-on experience in radiolabeling for diagnostic and therapeutic applications; experience with isotopes such as Ga-68, F-18, Cu-64, and In-111 is a plus.
• Experience developing automated radiolabeling methods, including design for GMP manufacturing of radiolabeled drug products.
• Proficiency in analytical techniques such as HPLC, radio-HPLC, radio-TLC, and other QC methods relevant to radiopharmaceutical production.
• Strong problem-solving skills and ability to lead and execute complex scientific projects independently.
• Effective communicator with strong project management skills and experience collaborating in cross-functional teams including QA, regulatory, R&D, and operations.
• Knowledge of regulatory requirements for radiopharmaceutical development and manufacturing across jurisdictions, with experience supporting CMC documentation.

What's in it for you:

At Alpha-9 Oncology, we offer a competitive and comprehensive benefits package designed to support all employees. Our benefits include a competitive salary, bonus, equity, 20 vacation days, 5 sick days, a technology allowance, and commuter reimbursement.We also provide generous retirement savings plans with employer matching, extended health benefits, and paid holidays, tailored to local standards in each region. While specific offerings may vary by location, our commitment to fostering a supportive and rewarding work environment is consistent across the company.

Company Summary

Alpha-9 Oncology is a clinical-stage biotechnology company pioneering radiopharmaceutical innovation for solid tumors. Our proprietary scaffolds, composed of optimized binders, linkers, chelators, and radioisotopes, enable targeted radiation delivery to cancer cells, minimizing harm to surrounding healthy tissue. Focusing on innovative targeting moieties, we develop molecules tailored for precise tumor targeting.

Our comprehensive platform integrates imaging and therapeutic studies to ensure effective radiation delivery and improved patient outcomes. With a robust pipeline entering clinical trials and strong support from leading healthcare investors, Alpha-9 is positioned for rapid growth and advancement in cancer therapy.

More about Alpha-9 Oncology

Alpha-9 Oncology is committed to fostering a diverse and inclusive workplace and is proud to be an Equal Opportunity Employer. We provide employment opportunities to all qualified applicants without regard to race, ethnicity, religion, age, sex, gender identity or expression, sexual orientation, disability, marital status, family status, national origin, or any other characteristic protected by applicable federal, provincial, or local laws where we operate.

We are dedicated to providing reasonable accommodations to qualified applicants and employees to ensure that everyone can perform their essential job functions in an inclusive environment. For inquiries regarding accommodations in the hiring process or for current employees, please contact a member from our Talent Acquisition team.

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