Research Associate (Grade 6) or Research Fellow (Grade 7) in The Development and Application Of[...]

The University of Manchester; Manchester; On-site; CAD 60,000 - 80,000; Full time

Job summary

An exciting opportunity at a leading university for a Research Associate or Fellow to contribute to the development of innovative mass spectrometry techniques in the field of virus-based drug products. This interdisciplinary role allows for significant collaboration and advancement in understanding large protein complexes and their applications in biomedicine.

Benefits

Market-leading pension scheme

Employee health and wellbeing services

Generous annual leave entitlement

Additional paid closure over Christmas

Discounts at major retailers

Qualifications

• Extensive mass spectrometry experience required.
• Experience with constructing experimental setups and data analysis.
• Knowledge of protein assemblies and DNA content analysis preferred.

Responsibilities

• Build, install, and test novel mass spectrometry instruments.
• Collaborate with academic and industry partners on research.
• Analyze and characterize MDa protein assemblies and AAV vectors.

Skills

Mass Spectrometry

Instrument Development

Microscopy

Education

PhD in relevant field

Job description

Research Associate (Grade 6) or Research Fellow (Grade 7) in The Development and Application Of New Mass Spectrometry Methods To Characterise Virus Based Drug Products

We are seeking a motivated individual with extensive mass spectrometry experience to develop a new instrument and study MDa protein assemblies. Based in Prof. Perdita Barran's team at the Michael Barber Centre for Collaborative Mass Spectrometry, you will collaborate with experts from TrueMass Ltd., Fasmatech Ltd., and UoM.

Your main responsibilities include building, installing, and testing a novel geometry CDMS instrument with an improved ESI source for MDa ion transmission. The project involves collaboration with Prof. Brian Biggar (UoEdinburgh) and Pharmaron Ltd., applying the technology to analyze the DNA content of recombinant AAV vectors.

You will compare this instrument's capabilities with existing mass spectrometry platforms and other methods. Additionally, you will build a stage for characterizing MDa complexes via microscopy, develop SOPs for the instrument using standard protein assemblies, and apply it to analyze AAVs, especially focusing on filled versus empty capsids and their efficacy in animal models.

This interdisciplinary project offers opportunities to explore the study of heavily glycosylated protein assemblies and other large complexes, contributing to advancements in virus-based drug product characterization.

What Can You Expect In Return

• Market-leading pension scheme
• Employee health and wellbeing services, including an Employee Assistance Programme
• Generous annual leave entitlement plus bank holidays
• Additional paid closure over Christmas
• Discounts at major retailers

The University promotes inclusion and diversity, ensuring equal opportunity for all applicants. Flexible and hybrid working arrangements may be considered. Please note that applications from recruitment agencies are not accepted.

For inquiries, contact Perdita Barran at [e-mail] or email [e-mail]. Technical support is available at this link. The vacancy closes at midnight on the specified deadline. Refer to the Further Particulars document for detailed person specification criteria.