Principal Scientist Dx CMC Radiochemistry

Oncology; Vancouver; On-site; CAD 90,000 - 130,000; Full time

Job summary

A leading biotechnology company in Vancouver seeks a Principal Scientist in CMC Radiochemistry. The role involves developing radiolabeling processes for radiopharmaceuticals, collaborating with cross-functional teams, and contributing to innovative cancer therapies. Enjoy a dynamic work environment with opportunities for growth and a competitive benefits package.

Benefits

Competitive salary

Bonus

Equity

20 vacation days

5 sick days

Technology allowance

Commuter reimbursement

Retirement savings plans

Extended health benefits

Paid holidays

Qualifications

• 5+ years' experience in radiopharmaceutical process development.
• Hands-on experience with diagnostic and therapeutic radioisotopes.

Responsibilities

• Lead radiochemistry experiments for diagnostic applications.
• Collaborate with teams to define project goals and timelines.
• Develop quality control procedures for radiopharmaceuticals.

Skills

Project Leadership

Communication

Analytical Methods

Education

Ph.D. or M.Sc. in Radiochemistry

Tools

HPLC

radio-HPLC

radio-TLC

Job description

Principal Scientist Dx CMC Radiochemistry

Your Impact

Alpha-9 Oncology is seeking a highly motivated Senior/Principal Scientist, CMC Radiochemistry with a strong background inradiolabeling processes and analytical testing methods for peptide/small molecule-based radiopharmaceuticalsto join our innovative CMC Radiochemistry group. In this role, you will collaborate closely with cross-functional teams, includingR&D, regulatory, and external CDMO partners, to drive the development and delivery of novel radiolabeled diagnostic compounds for both pre-clinical and clinical applications. You’ll have the chance to make a real impact on our mission while enjoying a dynamic work environment that fosters learning and career progression.

Reporting to the Director of Diagnostic Radiopharmaceutical Development, you will play a key role in shapingour radiopharmaceutical development program, enabling you to see the direct results of your contributions and grow alongside a passionate team. This role is based in ourVancouver officewith flexibility for hybrid work.

How You'll Contribute

• Lead radiochemistry experiments to develop robust radiolabeling processes and clinical formulations that meet target product profiles for diagnostic applications.
• Collaborate with multidisciplinary teams to define project goals and timelines, while supervising junior radiochemists and driving process improvements.
• Develop quality control procedures, analytical methods, and specifications for radiopharmaceutical drug products, in coordination with analytical chemists and external partners (CROs, CDMOs).
• Design and optimize manual and automated radiolabeling processes, with a focus on continuous improvement and process optimization.
• Conduct root cause investigations for process or synthesis failures, troubleshoot issues, and enhance product development knowledge.
• Author and review technical documents (SOPs, reports, test methods, regulatory documents), ensuring compliance with radiation safety regulations and industry standards.

The Skills you Bring

• Ph.D. or M.Sc. in Radiochemistry, Chemistry, Analytical Chemistry, Nuclear Engineering or related field, or equivalent experience.
• 5+ years' experience in radiopharmaceutical process development, formulation development, production, manufacturing, or tech transfer.
• Hands-on experience using diagnostic and therapeutic radioisotopes (e.g., Ga-68, F-18, Cu-64 and In-111) is a plus.
• Expertise in developing automated radiolabeling processes, including for GMP production or radiolabeled drug products.
• Proficient in analytical methods like HPLC, radio-HPLC, radio-TLC, and quality control for radiopharmaceutical production.
• Strong project leadership skills with a proven ability to manage multiple projects simultaneously.
• Proven experience working in managing cross-functional projects with the ability to prioritize and handle multiple tasks efficiently.
• Effective communicator with experience collaborating cross-functionally across teams such as QA, regulatory affairs, R&D, analytical, and operations.
• Familiarity with regulatory requirements for radiopharmaceutical development and production, along with experience in preparing CMC documentation.
  
  

What's in it for you:

At Alpha-9 Oncology, we offer a competitive and comprehensive benefits package designed to support all employees. Our benefits include a competitive salary, bonus, equity, 20 vacation days, 5 sick days, a technology allowance, and commuter reimbursement.

We also provide generous retirement savings plans with employer matching, extended health benefits, and paid holidays, tailored to local standards in each region. While specific offerings may vary by location, our commitment to fostering a supportive and rewarding work environment is consistent across the company.

Company Summary

Alpha-9 Oncology is a clinical-stage biotechnology company pioneering radiopharmaceutical innovation for solid tumors. Our proprietary scaffolds, composed of optimized binders, linkers, chelators, and radioisotopes, enable targeted radiation delivery to cancer cells, minimizing harm to surrounding healthy tissue. Focusing on innovative targeting moieties, we develop molecules tailored for precise tumor targeting.

Our comprehensive platform integrates imaging and therapeutic studies to ensure effective radiation delivery and improved patient outcomes. With a robust pipeline entering clinical trials and strong support from leading healthcare investors, Alpha-9 is positioned for rapid growth and advancement in cancer therapy.

More about Alpha-9 Oncology

Alpha-9 Oncology is committed to fostering a diverse and inclusive workplace and is proud to be an Equal Opportunity Employer. We provide employment opportunities to all qualified applicants without regard to race, ethnicity, religion, age, sex, gender identity or expression, sexual orientation, disability, marital status, family status, national origin, or any other characteristic protected by applicable federal, provincial, or local laws where we operate.

We are dedicated to providing reasonable accommodations to qualified applicants and employees to ensure that everyone can perform their essential job functions in an inclusive environment. For inquiries regarding accommodations in the hiring process or for current employees, please contact a member from our Talent Acquisition team.

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