Nucleic acid chemistry/DNA damage/mass spectrometry

Univeristé de Sherbrooke; Sherbrooke; On-site; CAD 60,000 - 80,000; Full time

Job summary

Une entreprise innovante recherche un candidat dynamique pour un poste postdoctoral de 2 ans dans le domaine des sciences de la radiation. Le candidat idéal aura une solide formation en chimie biologique et analytique, ainsi qu'une expérience pratique en spectrométrie de masse. Ce poste offre l'opportunité de travailler au sein d'une équipe dynamique et d'interagir avec des centres de recherche renommés. Les résultats prometteurs des essais précliniques rendent ce rôle essentiel pour comprendre les mécanismes d'action des thérapies de radiothérapie. Si vous êtes motivé et passionné par les sciences de la radiation, cette opportunité est faite pour vous.

Qualifications

• Expérience pratique en spectrométrie de masse requise.
• Connaissance des dommages et réparation de l'ADN souhaitée.

Responsibilities

• Examiner les aspects structurels et quantitatifs des dommages à l'ADN.
• Développer des méthodes novatrices pour évaluer les dommages à l'ADN.

Skills

Chimie biologique/analytique

Dommages et réparation de l'ADN

Spectrométrie de masse

Education

Doctorat en chimie ou domaine connexe

Tools

Méthodes enzymatiques

Job description

Nucleic Acid Chemistry/DNA Damage/Mass Spectrometry

Applications are invited for a 2-year postdoctoral position in the laboratory of Prof. J. Richard Wagner. The position is available from January 2025 (open until filled). The salary is commensurate with that proposed by national agencies and dependent on the candidate’s expertise.

Flash radiotherapy using high dose rate electron or proton beams significantly spares healthy tissue while irradiating tumors with similar efficiency as low-dose rate conventional radiation. Recent results from animal and preclinical trials are extraordinarily promising although the exact mechanism of action in sparing normal tissue is poorly understood. To understand the mechanism of action, the candidate will examine structural and quantitative aspects of DNA damage related to Flash in comparison to conventional radiation. The candidate will develop novel methods to assess DNA damage in cells, isolated DNA and model compounds using methods based on mass spectrometry and enzymatic assays.

Place of Work

The successful applicant will join a dynamic team with expertise in various aspects of the radiation sciences. The candidate will have the opportunity to interact and participate in exchange visits between two internationally renowned research centers. The department for the sciences of medical imaging and radiation at the Université de Sherbrooke is composed of 30 research professors, 16 clinicians, and a large team of highly qualified personnel.

How to Apply

We invite applications from highly self-motivated individuals with a strong interest in the radiation sciences. A background in biological/analytical chemistry, DNA damage and repair, with hands-on experience in mass spectrometry is preferred. Candidates holding, or shortly expecting to be awarded, a PhD degree in related fields are encouraged to apply. Applicants should have relevant expertise and publications as first author. Interested candidates should send a CV including publication record, a brief description of their research interests, and contact details for two referees to Prof. J. Richard Wagner.

Respond to

Prof. J. Richard Wagner, Department of Sciences of Medical Imaging and Radiation, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke (Québec) J1H 5N4. Tel (office): 819-821-8000 ext. 72717

Seniority Level

Internship

Employment Type

Full-time

Job Function

Research, Analyst, and Information Technology