Mouse functional neurogenetics of rare diseases – Université de Montréal

Canadian Association for Neuroscience; Montreal; On-site; CAD 100,000 - 125,000; Full time

Job summary

Join a vibrant and innovative lab focused on unraveling the mysteries of neurodevelopment and rare neurological diseases. This position offers a unique opportunity to work with cutting-edge mouse and zebrafish models, contributing to groundbreaking research that explores the function of an unknown gene in the central nervous system. As a post-doctoral fellow, you will engage in a dynamic environment with the autonomy to thrive, participate in international congresses, and collaborate with a vast network of experts. If you are passionate about neuroscience and eager to make a significant impact, this role is perfect for you.

Benefits

Participation in international congresses

Dynamic lab environment

Technical support from CRCHUM platforms

Access to patient cells and models

Qualifications

• Extensive expertise in neurodevelopment studies and molecular biology techniques.
• Experience with behavioural analysis and EEG recording is a plus.

Responsibilities

• Analyze neurodevelopment in various conditional KO mouse models.
• Investigate gene function related to central nervous system and seizures.

Skills

Neurodevelopment in mice

Molecular biology analytical techniques

Behavioural analysis in mice

EEG recording in mice

Bioinformatics data analysis

Education

PhD in Neuroscience or related field

Tools

KO mouse models

Zebrafish models

Human cells

Job description

Since 2020, we have collaborated with a patient association with whom we have discovered new genetic variations in a gene that had never before been implicated in neurological diseases. We have access to patient cells and have generated numerous loss-of-function models in this gene: KO mouse model, humanized mouse model, conditional KO mouse model, KO zebrafish models, KO cell lines, iPSC-KO. Our recent work has validated the pathogenicity of patient variants and, more broadly, the loss of function of this gene in neurodevelopmental diseases. Over the next few years, we aim to decipher the yet unknown function of this gene during neurodevelopment and central nervous system function. The project will focus on the analysis of neurodevelopment in different conditional KO mouse models and will also investigate how perturbations in this gene can affect the function of the central nervous system, particularly causing seizures.

Expertise

We are looking to recruit a passionate post-doctoral fellow with extensive expertise in the study of neurodevelopment in mice and in-depth knowledge of neurogenesis. Expertise in molecular biology analytical techniques applied to mice is required. Expertise in behavioural analysis and EEG recording in mice is a plus, along with expertise in bioinformatics data.

• All models are already generated
• Working on an entirely new subject with a gene whose function is totally unknown
• Project funded for 3 years
• Participation in one international congress per year to present research data
• A young, dynamic lab autonomy to thrive
• A vast network of collaborators (clinicians, geneticists, researchers)
• Modern premises in the heart of downtown Montreal

Our Lab

Our laboratory is interested in dissecting the molecular mechanisms underlying rare neurological diseases. We take advantage of the ease of use of the zebrafish model, but also combine it with mouse models and human cells.

• Technical support from more than 19 platforms at the CRCHUM

Contact Information

Send a cover letter, CV, and at least two letters of recommendation to [e-mail]. There are no closing dates for applications, and analysis of the files may stop as soon as a candidate has been selected.

Get in touch if you have any questions or comments: