Downstream Manager – Night Shift

BioTalent Canada; Toronto; On-site; CAD 110,000 - 140,000; Full time

Job summary

Sanofi is seeking a Downstream Operations Manager for the B200 facility to lead downstream manufacturing in a cGMP environment, directing union staff during the night shift and ensuring timely batch releases.

You will drive planning/execution, maintain GMP compliance with QA, mentor staff, and coordinate with Upstream/Buffer & Logistics as needed. Experience with DeltaV and electronic batch records is preferred.

Qualifications

• Bachelor’s degree in science or engineering with 3–5 years of pharma production; people management experience.
• Experience with Manufacturing Automation (e.g., DeltaV) and electronic batch records is a plus.

Responsibilities

• Oversee downstream manufacturing operations in a cGMP facility.
• Schedule and execute production plans; manage union staff on night shift.
• Ensure GMP documentation and QA alignment; lead continuous improvement initiatives.

Skills

People management

Leadership

GMP knowledge

Education

Bachelor’s degree in science/engineering

Tools

DeltaV

Electronic batch records

Job description

Join a global network that powers how Sanofi delivers — seamlessly, purposefully, and at scale. In Manufacturing & Supply, you’ll help reimagine how life-changing treatments reach people everywhere, faster.

Mission

The B200 Downstream Operations Manager is responsible for the Downstream manufacturing operations in compliance with cGMP. The manager is responsible for the daily activities of unionized staff in a cGMP facility in compliance with company policies. This includes responsibility for the scheduling and execution of all operations with GMP documentation. This also includes active involvement in B200 project activities from design, and through all stages to commercial production.

About Sanofi

We’re an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives.

Main Responsibilities:

1. Technical 10%

• Provide troubleshooting and problem-solving guidance for daily manufacturing issues, and implement preventative/corrective actions
• Participate and support the ongoing usage of digital technology (e.g. electronic batch record and e-logbooks) into manufacturing process in the new facility to reduce costs and to improve quality, efficiency and delivery

2. Planning and Execution 40%

• Develop and execute production schedules for full scale manufacturing, ensure that production activities are executed as per defined schedules
• Lead operations team execution on the shop floor for equipment, processes, and facilities. Monitor and communicate team performance with respect to deliverables using visible metrics and SMS tools
• Support execution of operating budget and staffing for operations and related continuous improvement activities
• Develop communication approach for Operations topics to ensure milestones are met (escalation, cascading)

3. cGMP Compliance & Quality 20%

• In collaboration with QA, ensure compliance with GMP requirements, develop quality continuous improvement initiatives, develop staff quality culture, and GMP knowledge.
• Ensure that all Operating Procedures, training plans, and manufacturing documentation are current, developed in adherence to global and site policies, and completed in a timely manner.
• Through appropriate shop floor oversight, ensure that facilities & equipment are compliant, and that process and environmental deviations are addressed in an expedited and compliant manner to meet requirements for the batch release schedule.
• Support internal and external regulatory audits/inspections and coordinate appropriate responses and CAPAs

4. People and Development 15%

• Organize and develop staff to ensure a high performing team. Provide individual feedback on staff objectives and development, coaching each team member on personal development milestones.
• Contribute to the B200 Operations management team, communicate and co-operate cross-functionally to achieve project and operational goals.
• Hire and on-board new employees, manage team attendance and performance.
• Develop and oversee technical training plan to ensure training compliance for all shop floor staff
• Implement lean management systems and continuous improvement of processes established under SMS.
• Challenge status quo; identify and lead initiatives to increase process efficiency, quality and/or yield. Implement solutions or changes via change control, plan and manage facility and organization improvements
• Provide metrics and other reports as requested, including the scheduling of PM plans, spare parts, BOMs

6. Safety 5%

• Ensure that employees work within the policies, procedures and regulations including responding promptly to all health and safety concerns or incidents; reportable incidents and accidents are reported; potential safety and health hazards are identified and known by staff and protective equipment are identified and used; continuous HSE awareness and improvement by integrating team with site and IA initiatives
• Cooperation with and assistance to the HSE management and Joint Health and Safety Committee in carrying out their functions
• Ensure complete and comprehensive safety training of staff
• Must have full understanding of all Hazard and Operability Analysis (HAZOP) and awareness of all Hazard Identification (HAZID) pertaining to Operations equipment and processes

Scope and dimensions

• This is an night shift role (10PM – 6AM (+1))
• Shift size : 4-5 Union staff
• Oversee Downstream operations in Building 200 and provide support to Upstream operations/ Buffer & Logistics when required
• Develop and ensure consistency of communication across shifts

About You

Education and Experience:

• Minimum bachelor’s in science /engineering with 3-5 years of experience in pharmaceutical production with people management responsibility
• Experienced with Manufacturing Automation (ex. DeltaV) and electronic batch records will be an asset

Competencies (Play-to-Win model) – key competencies the job holder will be evaluated on:

• Aim Higher
• Be Bold
• Act for patients
• Lead Together

Why Choose Us?

• Bring the miracles of science to life alongside a supportive, future-focused team.
• Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.
• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs.

This position is for a new vacant role that is now open for applications.

AI Usage

“Artificial Intelligence” refers to any systems that use automated processes, including algorithms and machine learning, to analyze data and make predictions, inferences, decisions, or recommendations without direct human involvement. These systems may process personal information to identify patterns, improve services, or support decision-making. The Company may use Artificial Intelligence for purposes including, but not limited to, resume screening and hiring, scheduling interviews or meetings, conducting surveys, matching skills with potential job openings, interview scoring, ensuring compliance with regulations applicable to our industry, and activities related to performance evaluation. Information collected and processed by the Company’s Artificial Intelligence systems may include the personal information detailed above and calendar availability. It excludes the information collected and processed for monitoring purposes. You should contact Human Resources if you have a question or concern regarding your personal information. You can also contact Canada’s Privacy Officer via Sanofi’s data subject request portal,can also be used torequest access or correction of your personal information and file a complaint.

Sanofi is an equal opportunity employer committed to diversity and inclusion. Our goal is to attract, develop and retain highly talented employees from diverse backgrounds, allowing us to benefit from a wide variety of experiences and perspectives. We welcome and encourage applications from all qualified applicants. Accommodations for persons with disabilities required during the recruitment process are available upon request.

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All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here.

Join Sanofi and step into a new era of science – where your growth can be just as transformative as the work we do. We invest in you to reach further, think faster, and do what’s never-been-done-before. You’ll help push boundaries, challenge convention, and build smarter solutions that reach the communities we serve. Ready to chase the miracles of science and improve people’s lives? Let’s Pursue Progress and Discover Extraordinary – together.

At Sanofi, we provide equal opportunities to all regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity, protected veteran status or other characteristics protected by law.

Final compensation will be determined based on demonstrated experience, skills, location, and other relevant factors. Employees may be eligible to participate in Company employee benefit programs.