Cancer Epigenomics Research Tech - 3D Genome & Organoids

University Health Network; Toronto; On-site; CAD 83,276,000 - 125,827,000; Full time

Benefits offered by this job

HOOPP pension plan

Transit access

Flexible work environment

Job summary

University Health Network invites applications for a Research Technician in cancer epigenomics at the Princess Margaret Cancer Centre. The role focuses on chromatin architecture, epigenetic regulation, and tumor heterogeneity using 3D genome mapping and multi-omics approaches.

You will support and execute experiments, prepare sequencing libraries, work with patient-derived models, and collaborate across a multidisciplinary team to advance translational cancer research.

Qualifications

• Bachelor's degree in Molecular Biology, Cancer Biology, Genetics, Genomics, Biochemistry, Cell Biology, or a related field required
• Master's degree an asset
• Minimum of 3 years of relevant wet-lab research experience required
• Strong hands-on experience with molecular biology and genomics techniques
• Experience with next-generation sequencing library preparation
• Experience with chromatin-based or epigenomics assays such as ATAC-seq, CUT&RUN, CUT&Tag, Hi-C, HiChIP, Capture-C, or related methods
• Experience with patient-derived organoid culture or other cancer model systems
• Ability to follow, optimize, and troubleshoot complex experimental protocols
• Strong organizational skills and attention to detail
• Excellent communication skills and fluency in English
• Ability to work effectively in a collaborative, multidisciplinary research environment

Responsibilities

• Perform and optimize molecular biology and functional genomics experiments related to cancer epigenomics
• Carry out chromatin and sequencing-based assays (Hi-C, HiChIP, ATAC-seq, CUT&RUN, CUT&Tag) as applicable
• Prepare next-generation sequencing libraries across multiple assay types
• Work with patient-derived cancer models, including organoids
• Support sample processing, quality control, library prep, and sequencing submissions
• Maintain accurate experimental records and lab documentation
• Troubleshoot and optimize complex wet-lab protocols
• Coordinate with computational scientists to support data generation and progress
• Contribute to generation of figures, summaries, and experimental documentation
• Assist with ordering, reagent prep, equipment maintenance, and lab organization
• Support training of junior lab members
• Contribute to a collaborative and well-organized lab environment

Skills

Wet-lab experience

Genomics techniques

English communication

Education

Bachelor's degree in Molecular Biology or related field

Master's degree an asset

Tools

NGS library prep

Hi-C / HiChIP

ATAC-seq

CUT&RUN

CUT&Tag

Capture-C

Organoid culture

Job description

University Health Network invites applications for a Research Technician in cancer epigenomics at the Princess Margaret Cancer Centre. The role focuses on chromatin architecture, epigenetic regulation, and tumor heterogeneity using 3D genome mapping and multi-omics approaches.

You will support and execute experiments, prepare sequencing libraries, work with patient-derived models, and collaborate across a multidisciplinary team to advance translational cancer research.