Annotation Analyst, Laboratory Medicine

University Health Network; Toronto; On-site; CAD 52,000 - 78,000; Full time

Benefits offered by this job

Competitive offer packages

HOOPP pension

Transit access

Flexible work environment

Opportunities for development

Job summary

University Health Network处于加拿大安大略省多伦多，现招聘Annotation Analyst，隶属Clinical Genomicsteam，协助临床基因组诊断实验室的变异分析与报告撰写。该岗位需要掌握NGS数据分析、变异评估以及相关数据库应用，能在跨职能团队环境中工作并保持高效质量控制。

职位强调独立学习和快速吸收新数据，关注临床相关性及科研前沿。提供稳定永久全职工作、轮班覆盖24/7，以及全面福利。

Qualifications

• Master's degree in Molecular Genetics or related field.
• Minimum 6 months relevant experience in clinical genomics.
• Knowledge of genetic databases and variant assessment techniques.
• Experience with NGS platforms and data interpretation.

Responsibilities

• Investigate clinical relevance of variants detected by sequencing.
• Draft concise variant interpretations for reporting.
• Analyze NGS and other laboratory data including somatic/germline testing.
• Perform database/reporting tasks related to variant analyses.
• Maintain quality control and work with cross-functional teams.
• Participate in test development and safety/quality programs.
• Communicate with laboratory staff and external clients to coordinate services.
• Contribute to education and continuous improvement initiatives.
• Uphold patient confidentiality and hospital mission.

Skills

Genetic variant assessment

NGS data analysis

Problem solving

Documentation & reporting

Independent work

Cross-functional collaboration

Verbal and written communication

Education

Master's in Molecular Genetics or related discipline

Tools

HGMD

COSMIC

gnomAD

cBioPortal

ClinVar

NGS platforms & analysis

Job description

• Compensation: CAD 37.85 - CAD 56.77 - hourly

Company Description

UHN is Canada’s #1 hospital and the world’s #1 publicly funded hospital. With 10 sites and more than 44,000 TeamUHN members, UHN consists of Toronto General Hospital, Toronto Western Hospital, Princess Margaret Cancer Centre, Toronto Rehabilitation Institute, The Michener Institute of Education and West Park Healthcare Centre. As Canada's top research hospital, the scope of biomedical research and complexity of cases at UHN have made it a national and international source for discovery, education and patient care. UHN has the largest hospital-based research program in Canada, with major research in neurosciences, cardiology, transplantation, oncology, surgical innovation, infectious diseases, genomic medicine and rehabilitation medicine. UHN is a research hospital affiliated with the University of Toronto.

UHN’s vision is to build A Healthier World and it’s only because of the talented and dedicated people who work here that we are continually bringing that vision closer to reality.

Union: Non-Union
Number of Vacancies: 1
New or Replacement:New
Site: All Sites
Department: Laboratory Medicine Program, Advanced Diagnostics
Reports to: Senior Manager, Advanced Diagnostics
Hours: 37.5 hours per week
Salary:$37.85 to $56.77 per hour
Shifts: All Shifts 24/7
Status:Permanent Full Time
Closing Date: October 21, 2026

Position Summary
Join UHN's Laboratory Medicine Program, Canada's largest hospital diagnostic lab and a global leader in academic labs. With over 30 million tests per year and 1,300 outpatients served daily, we are at the forefront of pathology and clinical testing. Embrace innovation and contribute to ground-breaking research, education, and exemplary service. Join our dynamic team of 700 dedicated staff and play a pivotal role in shaping the future of laboratory medicine.

As an integral member of the Clinical Genomicsteam, the Annotation Analystplays a key role in supporting the efforts of the Clinical Genome Diagnostics laboratory.

Duties

• Utilizing software tools, databases and primary literature to investigate the clinical relevance of variants detected by genetic methods including next-generation sequencing (NGS)
• Drafting concise variant interpretations
• Utilizing practical and theoretical knowledge for the analysis of NGS and other laboratory data, including somatic and germline testing
• Completing required database and reporting activities related to variant analyses
• Completing assigned workload in a manner to ensure the efficient operation of the clinical laboratory
• Participating in molecular profiling test development activities with laboratory technologists
• Maintaining quality control standards in assigned area
• Participating in communication activities to maintain and continually enhance the co-operation and coordination of services with other laboratory staff and with external lab clients
• Participating in professional development, teaching/education activities, safety and quality improvement programs to ensure excellence in the provision of services
• Adhering to Hospital and departmental mission and value statements while maintaining patient confidentiality

Qualifications

• Master's degree in Molecular Genetics or related discipline required at minimum
• 6 months minimum of relevant experience required
• Knowledge of and experience with molecular genetic variant assessment techniques
• Knowledge of and experience with the use of genetic databases / resources and software (e.g. HGMD, COSMIC, gnomAD, cBioPortal, CICiC, ClinVar)
• Knowledge of and experience with the theory and application of NGS platforms and NGS analysis
• Knowledge of the theory and practice of current NGS laboratory procedures, instruments, equipment and special techniques
• Excellent problem recognition and problem solving skills
• Effective organizational, time management and prioritization skills
• Excellent verbal and written communication skills
• Ability to learn quickly, take in and distill large amounts of information and apply scientific knowledge
• Scientific curiosity and interest to stay on top of emerging scientific data and trends as it pertains to the role
• Demonstrated ability to take initiative, multitask and think critically
• Ability to work independently and with cross-functional team members

Additional Information

In addition to working alongside some of the most talented and inspiring healthcare professionals in the world, UHN offers a wide range of benefits, programs and perks. It is the comprehensiveness of these offerings that makes it a differentiating factor, allowing you to find value where it matters most to you, now and throughout your career at UHN.

• Competitive offer packages
• Government organization and a member of the Healthcare of Ontario Pension Plan (HOOPP https://hoopp.com/ )
• Close access to Transit and UHN shuttle service
• A flexible work environment
• Opportunities for development and promotions within a large organization
• Additional perks (multiple corporate discounts including: travel, restaurants, parking, phone plans, auto insurance discounts, on-site gyms, etc.)

Current UHN employees must have successfully completed their probationary period, have a good employee record along with satisfactory attendance in accordance with UHN's attendance management program, to be eligible for consideration.

Please be advised that a Criminal Record Check may be required of the successful candidate. Should it be determined that any information provided by a candidate be misleading, inaccurate or incorrect, UHN reserves the right to discontinue with the consideration of their application.

UHN is an equal opportunity employer committed to an inclusive recruitment process and workplace. Requests for accommodation can be made at any stage of the recruitment process. Applicants need to make their requirements known.