Senior/Principal Scientist Biotransformations

7555-Janssen Pharmaceutica NV Legal Entity; Geel; Sur place; EUR 79 800 - 137 770; Plein temps

Avantages offerts par ce poste

Base pay range

Annual bonus potential

Health benefits

Résumé du poste

Johnson & Johnson Beerse, Belgium seeks a highly motivated Senior/Principal Scientist to support drug discovery with translational pharmacokinetics/metabolism expertise. You will lead metabolite profiling, perform LC-MS analyses, and drive biotransformation studies in a global team.

The role requires a PhD in a related field, strong MS skills, and experience with diverse modalities. English is the working language; Beerse location offers cutting-edge labs.

Qualifications

• PhD or equivalent in Medicinal/Organic Chemistry, Pharmaceutical Sciences, Biochemistry, Pharmacokinetics or Drug Metabolism.
• Hands-on MS structure elucidation and biotransformations experience.
• Knowledge of enzymes in biotransformations and metabolite profiling.
• Experience with oligonucleotides/peptides/proteins is an asset.
• English as working language; ability to interact in an international team.

Responsabilités

• Manage and coordinate metabolite profiling and identification studies for diverse modalities.
• Perform LC analysis with MS, UV and radioactive detection; develop methods and analyze data.
• Serve as SME for biotransformations; suggest follow-up experiments.
• Communicate data and relevance to cross-functional teams and partners.
• Keep up with advances in MS, automation, and related techs to increase throughput.

Connaissances

Mass spectrometry

Biotransformations

Bioinformatics

Team collaboration

Analytical thinking

English communication

Formation

PhD in Medicinal/Organic Chemistry

Pharmaceutical Sciences

Biochemistry

Pharmacokinetics/Drug Metabolism

Description du poste

Overview

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com. As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

Job Function: Discovery & Pre-Clinical/Clinical Development

Job Sub Function: Pharmacokinetics & Pharmacometrics

Job Category: Scientific/Technology

Locations: Beerse, Antwerp, Belgium

Our Translational ADME Biotransformation team in Beerse, Belgium, is looking for a highly motivated Senior or Principal Scientist to support drug discovery and development programs. The team is part of the department of Translational Pharmacokinetics/Pharmacodynamics and Investigative Toxicology (TPPIT) and plays a pivotal role in support of drug metabolism related studies for small and large molecule drug discovery and development programs as well as in developing and applying advanced analytical chemistry solutions to solve mechanistic questions. We are a highly motivated team, and our laboratories are state-of-the-art. As part of the global Translational ADME community within TPPIT, you will have access to a large arsenal of in silico, in vitro, in vivo and analytical tools and the vast expertise of colleagues at our various research sites in Belgium and the United States.

Responsibilities

• To manage and coordinate metabolite profiling and identification studies for a broad range of modalities (small molecules, degraders, peptides, oligonucleotides, etc.), including design, plan and conduct of in vitro incubations, perform high quality analysis and write high quality scientific reports
• To perform liquid chromatography analysis with MS, UV and radioactive detection, including method development and data analysis and interpretation
• Serve as a subject matter expert for biotransformations, putting data into broader context and suggest and develop follow-up in vitro or in vivo experiments
• Effectively communicate data and their relevance to multidisciplinary project teams, management, and potential partners through internal and external presentations and publications
• To keep abreast with the current advances in MS, automation and related technologies and apply new technologies and methods to increase sensitivity, quality and throughput

Qualifications

• PhD in Medicinal/Organic Chemistry, Pharmaceutical Sciences, Biochemistry, Pharmacokinetics, Drug Metabolism or related field, or multiple years of relevant experience in the field of biotransformations
• Hands-on experience in structure elucidation using mass spectrometry
• In-depth knowledge of biotransformation reactions and enzymes involved
• Hands-on experience with non-small modalities (oligonucleotides, peptides and proteins) is an asset
• Experience with bioinformatics applications is an asset
• Experience in maintenance of chromatography and mass spectrometry instrumentation and developing and troubleshooting LC/RAD and LC/high-resolution MS assays
• Ability to independently diagnose and solve complex technical and scientific problems
• Team player with strong interpersonal skills in an international team setting, including a matrix environment
• Proven track record of scientific achievement and project influence through publications and other interactions
• The working language is English
• Seniority level is currently open and will be selected based on experience

Benefits

• Base pay range: €79,800.00 – €137,770.00
• Annual bonus potential and location-based benefits; vacation days, parental leave, bereavement leave, caregiver leave, volunteer leave, well-being reimbursement
• Programs for financial, physical and mental health; service anniversary and recognition awards; eligible dependents may participate in several insurance plans