Senior/Principal Scientist Biotransformations

Biopharma Careers; Beerse; Sur place; EUR 80 000 - 138 000; Plein temps

Avantages offerts par ce poste

Annual bonus

Vacation days

Parental leave

Bereavement leave

Caregiver leave

Well-being reimbursement

Health and wellness programs

Service awards

Résumé du poste

Johnson & Johnson Innovative Medicine in Beerse, Belgium, seeks a Senior/Principal Scientist to support drug discovery and development within Translational ADME Biotransformation. You will lead metabolite profiling, design incubations, and apply analytical chemistry to answer mechanistic questions in small and large molecules.

The role provides access to in silico, in vitro, in vivo tools and collaboration across global sites; English is the working language; seniority is determined by

Qualifications

• PhD in Medicinal/Organic Chemistry, Pharmaceutical Sciences, Biochemistry or related field, or equivalent experience.
• Hands-on MS-based structure elucidation and biotransformation expertise.
• Knowledge of biotransformation enzymes and reactions; experience with oligonucleotides/peptides is a plus.
• Experience maintaining chromatography/MS instrumentation and developing LC/RAD assays.
• Ability to diagnose and solve complex technical problems in a collaborative setting.

Responsabilités

• Coordinate metabolite profiling and identification studies across modalities.
• Perform LC-MS analyses with MS, UV and radioactive detection; develop methods and analyze data.
• Serve as SME for biotransformations and interpret data for project teams.
• Communicate findings to internal teams and external partners via presentations.
• Stay current with MS technologies and apply new methods to improve throughput.

Connaissances

Mass spectrometry

Biotransformation

Metabolite profiling

Analytical chemistry

Team collaboration

Formation

PhD in Medicinal/Organic Chemistry

Pharmacokinetics / Drug Metabolism related field

Outils

LC-MS instrumentation

LC/RAD and high-resolution MS assays

Bioinformatics tools

Description du poste

Job Function: Discovery & Pre-Clinical/Clinical Development

Job Sub Function: Pharmacokinetics & Pharmacometrics

Job Category: Scientific/Technology

All Job Posting Locations: Beerse, Antwerp, Belgium

Job Description:

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

Johnson & Johnson Innovative Medicine (J&J IM) develops treatments that improve the health of people worldwide. Research and development areas encompass cardiopulmonology, immunology, communicable diseases, neuroscience and oncology. Our goal is to help people live longer, healthier lives. We have produced and marketed many first-in-class prescription medications and are poised to serve the broad needs of the healthcare market – from patients to practitioners and from clinics to hospitals. To learn more about J&J Innovative Medicine, visit https:// www.jnj.com/innovative-medicine .

The Translational ADME Biotransformation team in Beerse, Belgium, is looking for a highly motivated Senior or Principal Scientist to support drug discovery and development programs. The team is part of the department of Translational Pharmacokinetics/Pharmacodynamics and Investigative Toxicology (TPPIT) and plays a pivotal role in support of drug metabolism related studies for small and large molecule drug discovery and development programs as well as in developing and applying advanced analytical chemistry solutions to solve mechanistic questions.

We are a highly motivated team, and our laboratories are state-of-the-arts. As part of the global Translational ADME community within TPPIT, you will have access to a large arsenal of in silico, in vitro, in vivo and analytical tools and the vast expertise of colleagues at our various research sites in Belgium and the United States.

Key Responsibilities

• To manage and coordinate metabolite profiling and identification studies for a broad range of modalities (small molecules, degraders, peptides, oligonucleotides, etc.), including design, plan and conduct of in vitro incubations, perform high quality analysis and write high quality scientific reports
• To perform liquid chromatography analysis with MS, UV and radioactive detection, including method development and data analysis and interpretation
• Serve as a subject matter expert for biotransformations, putting data into broader context and suggest and develop follow-up in vitro or in vivo experiments
• Effectively communicate data and their relevance to multidisciplinary project teams, management, and potential partners through internal and external presentations and publications
• To keep abreast with the current advances in MS, automation and related technologies and apply new technologies and methods to increase sensitivity, quality and throughput

Qualifications

• PhD in Medicinal/Organic Chemistry, Pharmaceutical Sciences, Biochemistry, Pharmacokinetics, Drug Metabolism or related field, or multiple years of relevant experience in the field of biotransformations
• Hands-on experience in structure elucidation using mass spectrometry
• In depth knowledge of biotransformation reactions and enzymes involved
• Hands-on experience with non-small modalities (oligonucleotides, peptides and proteins) is an asset
• Experience with bioinformatics applications is an asset
• Experience in maintenance of chromatography and mass spectrometry instrumentation and developing and troubleshooting LC/RAD and LC/high-resolution MS assays
• Ability to independently diagnose and solve complex technical and scientific problems
• Team player with strong interpersonal skills in an international team setting, including a matrix environment
• Proven track record of scientific achievement & project influence through publications and other interactions

The working language is English

Seniority level is currently open and will be selected based on experience.

Preferred Skills

• Clinical Data Management
• Clinical Pharmacology
• Clinical Trials Operations
• Coaching
• Consulting
• Critical Thinking
• Drug Development
• Drug Discovery Development
• Organizing
• Pharmacokinetics
• Pharmacology
• Pharmacometrics
• Program Management
• Report Writing
• Researching
• Research Proposals
• Scientific Research

The anticipated base pay range for this position is:

€79,800.00 - €137,770.00

Benefits

• an annual bonus with set target (% of pay) depending on pay grade / location, where the actual amount is based on the employees’ and companies’ performance of the previous calendar year, or sales commissions.
• vacation days
• parental leave for a minimum of 12 weeks
• bereavement leave
• caregiver leave
• volunteer leave
• well-being reimbursement
• programs for financial, physical and mental health
• service anniversary and recognition awards
• employees and in some location’s eligible dependents can participate in several insurance plans

*This is for informative purposes only. Amounts and actual benefits may vary by location and are subject to change.