Senior Clinical Pharmacology Manager

Agomab Therapeutics; Antwerpen; Hybride; EUR 80 000 - 100 000; Plein temps

Résumé du poste

A dynamic growth-stage biotech company in Antwerp is seeking a Senior Clinical Pharmacology Manager to lead clinical pharmacology efforts. In this role, you will contribute to the strategy and execution of clinical pharmacology plans for innovative small-molecule therapies, providing hands-on expertise and ensuring alignment with regulatory expectations. The ideal candidate will have over 10 years of experience in clinical pharmacology, a strong understanding of PK/PD, and the ability to thrive in a fast-paced environment. This position offers competitive compensation, flexible work arrangements, and significant growth opportunities.

Prestations

Competitive compensation

Flexible working arrangements

Professional growth opportunities

Qualifications

• 10+ years of experience in Clinical Pharmacology within biotech or pharma.
• Deep expertise in PK/PD, population modelling, and dose optimization.
• Comfortable operating as both an individual contributor and future leader.

Responsabilités

• Act as the primary Clinical Pharmacology lead of clinical assets.
• Develop and execute clinical pharmacology plans.
• Support regulatory interactions with FDA, EMA, and PMDA.

Connaissances

Scientific leadership

Clinical Pharmacology expertise

Project management

Fluent in English

Formation

PhD, PharmD, MD or equivalent degree in pharmacology

Outils

Population modelling

PBPK analysis

Description du poste

Senior Clinical Pharmacology Manager

Department: Clinical Development

Employment Type: Full Time

Location: Agomab Antwerp

Description

We are seeking a highly motivated, hands‑on Senior Clinical Pharmacology Manager to help build and grow our Clinical Pharmacology capabilities as we advance a portfolio of innovative small‑molecule therapies. Reporting to the VP, Clinical Development, you will initially serve as a key individual contributor to guide our programs from early translational development through clinical proof of concept and beyond while progressively taking on broader leadership responsibilities, with the opportunity to grow as the company and pipeline expand.

In this role, you will directly contribute to the design, execution, and interpretation of clinical pharmacology strategies, ensuring that PK/PD data, modelling, and translational insights inform key development decisions. As such, you will help shape the strategy required to support our organ‑restricted therapeutic approaches and late‑stage development ambitions.

Key Responsibilities

• Act as the primary Clinical Pharmacology lead of our clinical assets, with strong personal involvement in analyses, modelling, and study design.
• Develop and execute clinical pharmacology plans as an integrated part of clinical development plans.
• Provide hands‑on support for protocol development, clinical pharmacology study designs, and interpretation of emerging PK/PD and biomarker data.
• Ensure model‑informed decision making to guide compound progression from early clinical development through proof of concept.
• Independently perform and/or oversee population PK/PD, PBPK, and other quantitative analyses to support dose justification and risk assessment.
• Integrate nonclinical, translational, biomarker, and clinical data to support modelling strategies and regulatory‑ready outputs.
• Work closely with research, toxicology, clinical operations, regulatory, biometrics, and medical teams to ensure alignment and knowledge transfer.
• Support the selection, oversight, and scientific direction of CROs and external consultants.
• Contribute directly to clinical pharmacology sections of INDs, IBs, protocols, briefing documents, and regulatory responses.
• Support regulatory interactions with FDA, EMA, PMDA, and other agencies by providing data‑driven justifications for dose and development strategies, while ensuring activities are aligned with current regulatory expectations and industry best practices.
• Stay current with advances in translational pharmacology, organ‑targeted drug delivery, and quantitative modelling.
• Proactively identify opportunities to improve efficiency, scientific rigor, and impact of clinical pharmacology contributions.
• Support the selection, onboarding, and mentoring of future team members and external partners as the function grows.
• Gradually assume broader strategic and leadership responsibilities as the function matures.

Skills, Knowledge and Expertise

Who are you?

• You are a scientific and strategic leader with a passion for Clinical Pharmacology in a dynamic growth‑stage biotech.
• You hold a PhD, PharmD, MD, or equivalent degree in pharmacology, pharmaceutical sciences, or a related field.
• You bring 10+ years of experience in Clinical Pharmacology within biotech or pharma, with a strong emphasis on small‑molecule drug development.
• You possess deep expertise in PK/PD, population modelling, PBPK, dose optimization, and quantitative pharmacology.
• It’s a plus if you have hands‑on experience supporting or developing organ‑restricted or targeted pharmacology strategies.
• You are comfortable operating as both an individual contributor and a future people leader, with the ability to mentor others over time, fostering a collaborative and innovative work environment.
• You thrive in a dynamic, fast‑paced environment and bring strong organizational, strategic, and project management skills.
• You communicate fluently in English; additional languages are a plus.

Benefits

• A unique opportunity to shape Clinical Pharmacology in an ambitious, innovation‑driven biotech company.
• The chance to contribute directly to pioneering therapies addressing unmet medical needs.
• A collaborative, excellence‑focused team environment with room for personal and professional growth.
• Flexible working arrangements with the option to work three days per week from home (role based in Antwerp).
• Competitive compensation and benefits.
• A fast‑paced, agile, and empowering work environment.