Scientist Molecular Analytics Platform DNA/mRNA Next Generation Sequencing

Biopharma Careers; Rixensart; Sur place; EUR 59 000 - 99 000; Plein temps

Avantages offerts par ce poste

Annual bonus

Long term incentive program

Résumé du poste

Biopharma Careers is seeking a Scientist for the Molecular Analytics Platform in Belgium to develop and apply NAT‑based sequencing methods for mRNA vaccines. You will execute sequencing experiments, develop advanced analytics, and report results to internal stakeholders.

The role emphasizes collaboration with multinational teams, adherence to GMP practices, and driving method development from bench to release testing across Phase 1–3. Proficiency in English is required.

Qualifications

• PhD in molecular biology or related field with 3+ years post‑doc experience.
• Total education and experience of 5+ years in analytical sciences in the vaccine field.
• Experience with state‑of‑the‑art sequencing technologies (Illumina, Oxford Nanopore).
• Knowledge of nucleic acids synthesis, structure and analysis.
• Fluency in English and strong organizational skills.

Responsabilités

• Execute mRNA sequencing experiments (>60% bench work).
• Plan and execute sequencing using Illumina and Oxford Nanopore methods.
• Execute analytical methods for characterization of mRNA and plasmid DNA.
• Analyze data, generate reports, and present findings.
• Write scientific reports and ensure SOP compliance.
• Collaborate with cross‑functional teams locally and internationally.

Connaissances

Analytical Chemistry

Analytical Instrumentation

Analytical Laboratory

Analytical Thinking

Bioprocessing

Data Analysis Tools

Laboratory Reports

Method Development

Technical Problem-Solving

Formation

PhD in Molecular Biology/Biotechnology/Bioengineering

5+ years in analytical sciences in vaccine field

Outils

Illumina sequencing

Oxford Nanopore Technologies

Description du poste

Analytical Development Department (Belgium) – Scientist Molecular Analytics Platform DNA/mRNA Next Generation Sequencing

Are you looking for a role in Molecular Biology/Nucleic-Acid-based Technologies (NAT) that enhances your scientific expertise and allows you to develop innovative analytical methods thereby contributing to the production of best-in-class medicines, including mRNA-based vaccines? If so, this Scientist role could be an ideal opportunity to explore.

Within the Analytical Development Department, the Molecular Analytics Platform is in charge of developing modern, state-of-the‑art molecular methods to detect, quantify and characterize nucleic acids at all stages of vaccines development. The hired Scientist will be in charge of executing, implementing, designing and developing methods for the detection, characterization and quantification of nucleic acids based on up-to-date nucleic acid technologies (NAT) and, in particular, methods aiming at sequencing mRNA vaccine related products using Illumina and Oxford Nanopore technologies (variant calling, integrity, capping, polyA-tail, 3D‑structure). The candidate will be in charge of the execution (and the reporting), the design and the development of NAT‑based analytical methods to support product and process development, to develop and transfer release methods for GMP testing for Phase 1, Phase 2 and Phase 3, according to Quality by Design principles and in partnership with Technical Research and Development functions, Quality and Regulatory.

Your responsibilities:

Execute mRNA sequencing experiments:

• Work on the bench in the labs (> 60%),
• Plan and execute mRNA sequencing experiments using methods based on Illumina and Oxford Nanopore technologies,
• Execute analytical methods for the characterization of mRNA and plasmid DNA,
• Analyze and interpretate data, including reporting and presentation,
• Write scientific reports,
• Ensure that SOP are applied and respected,
• Ensure that security rules are followed,
• Comply with his/her training matrix.

Contribute to method development, qualification and validation:

• Design and drive the development of next generation sequencing analytical methods for next generation mRNA vaccines using innovative NAT‑based technologies and automation in collaboration with the other teams of the global analytical platforms,
• In particular, ensure the development, qualification and validation of state‑of‑the‑art analytical sequencing methods for plasmid DNA damage, mRNA identity, integrity, capping, polyA-tail and content based on Illumina and Oxford Nanopore technologies,
• Ensure implementation of QbD (Quality by design) in the development of assays,
• Work closely with the bioinformatician team to develop, adapt and validate bioinformatics workflows for plasmid DNA damage, mRNA identity, integrity, capping, polyA-tail and content analyses,
• Analyze mRNA sequencing data, generate actionable insights, and communicate findings in written and oral presentations to internal teams and external stakeholders.

Act as a key subject matter expert:

• Think out‑of‑the‑box, using sound science, paying attention to details to continuously improve and shape the CMC strategy & framework,
• Act as a voice and ambassador of its department at various internal and external governance bodies and meetings.

Collaborate across teams:

• Interact with Belgium- and US‑based team members,
• Interact and act in a complex matrix with several stakeholders from different departments (Research, Development, QC, RA, QA),
• Interact with other GSK Vaccines Research and Development Centers (US and IT) and external partners.

Why you?

Basic Qualifications:

• PhD in Molecular Biology, Biotechnology, Bioengineering or a related scientific field with an additional 3+ years of post‑doc experience in the field,
• Total education and experience of 5+ years in analytical sciences in the vaccine field,
• Experience developing and implementing strategies with measurable outcomes,
• demonstrated expert knowledge (theoretical, practical and troubleshooting) and daily execution of state‑of‑the‑art next generation/high throughput sequencing technologies (e.g., Illumina and Oxford Nanopore Technologies),
• Demonstrated knowledge of the synthesis, structure, stability, degradation, chemical modifications and analysis of nucleic acids. In particular, demonstrated knowledge and understanding of plasmid DNA/mRNA structure, plasmid DNA damage, mRNA degradation, mRNA- and plasmid DNA-modifying enzymes, adaptor/oligonucleotide design and ligation, sequencing library design, and use of sequencing technologies beyond simple sequencing of nucleic acids (i.e., specialized library preparations),
• Demonstrated expertise in running bioinformatics pipeline is a plus,
• Fluency in English,
• Good organizational skills,
• Teamwork.

Preferred Qualifications:

• A good understanding of biopharma / vaccine development process,
• Good understanding of QbD principles. Driven by excellence, creativity, accountability, and flexibility in a collaborative and innovative environment,
• Capacity to synthesize messages and ability to defend scientific and technical decisions to have constructive interactions and allow to take the right decisions,
• Must have the ability to work with cross‑functional teams,
• Superlative presentation skills, across lines and levels and with senior stakeholders,
• Problem‑solving ability with limited information available to make decisions and interpretations,
• Positive, open and can‑do mindset,
• Critical thinking ability is a must,
• GMP basics is a plus.

Skills:

• Analytical Chemistry, Analytical Instrumentation, Analytical Laboratory, Analytical Thinking, Bioprocessing, Data Analysis Tools, Laboratory Reports, Method Development, Technical Problem‑Solving

Belgium Salary Range / Fourchette salariale – Belgique: EUR 59,400 to EUR 99,000The annual gross base salary range for new hires in this position is listed above for each applicable location. These ranges take into account a number of factors including the candidate’s skills, experience, education level and the market rate for the role. In addition, this position may offer an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. More detailed information on the total benefits package will be supplied during the recruitment process. This role is available for applicants from multiple locations, and therefore salary ranges for certain locations are also shown. Salary ranges for other locations are shown because some markets have pay transparency laws that require salary information on job postings, and those locations are potential job sites for this role. If salary ranges are not displayed in the job posting for a specific location or country, the relevant compensation will be discussed during the recruitment process. Please note salaries vary by country based on the candidate’s skills, experience, education level and the market rate for the role. Offers are typically made within the advertised range based on the candidate’s skills, experience and qualifications, with the upper end generally reserved for highly experienced candidates or other exceptional circumstances aligned with these criteria.Le salaire de base mensuel brut minimum pour les nouvelles recrues à ce poste est indiqué ci dessus pour chaque lieu applicable. Ce salaire de base mensuel brut minimum tient compte de plusieurs facteurs, notamment les compétences, l’expérience et le niveau de formation du/de la candidat(e), ainsi que le taux du marché pour le poste. En outre, ce poste peut donner droit à un bonus annuel ainsi qu’une éligibilité pour participer à notre programme de long term incentive basé sur des actions, en fonction du niveau du rôle. Des informations plus détaillées sur l’ensemble du package salarial seront fournies au cours du processus de recrutement. Ce poste étant ouvert à des candidat(e)s basé(e)s dans plusieurs pays, des fourchettes de salaire sont également indiquées pour certains lieux. Les fourchettes salariales pour d’autres localisations sont mentionnées parce que certains marchés ont des lois en matière de transparence salariale qui imposent que les informations sur les salaires soient affichées dans les offres d’emploi, et que ces pays sont les lieux potentiels pour ce poste. Si aucune fourchette salariale n’est indiquée dans l’offre d’emploi pour un lieu ou un pays spécifique, la rémunération correspondante sera discutée au cours du processus de recrutement. Veuillez noter les salaires varient selon le pays en fonction des compétences, de l’expérience, du niveau de formation du/de la candidat(e) et du taux du marché pour le poste. Les offres sont généralement faites dans la fourchette annoncée en fonction des compétences, des expériences, le de la…

If you have a disability and require assistance during the course of the selection process, you will have the opportunity to let us know what specific assistance you require in order to make suitable arrangements.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.