Postdoc on cofolding models for In-Silico Drug Discovery

Johnson & Johnson Innovative Medicine; Beerse; On-site; EUR 60,000 - 96,000; Full time

Benefits offered by this job

Annual bonus

Vacation days

Parental leave

Bereavement leave

Well-being reimbursement

Insurance plans

Job summary

Johnson & Johnson Innovative Medicine in Beerse, Belgium, is recruiting a Postdoctoral Scholar to join the In Silico Discovery department within Therapeutics Discovery. The role focuses on cofolding models for structure‑based drug discovery and AI/ML applications.

We seek early‑career scientists with strong training in computational chemistry, structural bioinformatics, or machine learning applied to biomolecular systems, able to design and benchmark fine‑tuning experiments.

Qualifications

• PhD in computational chemistry, structural bioinformatics, computational biology, or ML for biomolecular systems.
• Strong understanding of protein structure and structure‑based modeling concepts.
• Experience with AI/ML model development, training, fine‑tuning, and evaluation (e.g. PyTorch).
• Experience generating or working with structural datasets (protein–ligand or protein–protein complexes, MD data).
• Experience coding and developing research workflows in Python.
• Familiarity with HPC and GPU computing environments.
• Strong analytical, problem‑solving, and scientific communication skills.
• Track record of scientific deliveries, including peer reviewed publications and presentations.
• Fluency in English.
• Up to 10% travel domestically and internationally.

Responsibilities

• Design, run, and analyze fine‑tuning experiments for co‑folding and structure‑prediction models, benchmark against baselines.
• Generate, curate, and manage training/validation datasets to support model fine‑tuning and evaluation.
• Assess model performance using structural/task‑relevant metrics and contribute to best practices.
• Integrate fine‑tuned models into end‑to‑end discovery workflows with reporting and documentation.
• Collaborate with In Silico Discovery scientists across CADD, biologics, and AI/ML teams to align outputs with drug‑discovery needs.
• Contribute to internal scientific communication and publication‑ready summaries.
• Engage in external collaborations and consortia related to co‑folding and structural biology AI.
• Participate in professional development through training courses and conferences.

Skills

Protein structure

Structure-based modeling

AI/ML in drug discovery

Python programming

HPC

GPU computing

Scientific communication

Publications

Travel willingness

English fluency

Education

PhD in Computational chemistry

PhD in Structural bioinformatics

PhD in Computational biology

PhD in ML for biomolecular systems

Tools

PyTorch

Python

Job description

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, andsolutions are personal.Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.Learn more at jnj.com.

As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

Job Function

Career Programs

Job Sub Function

Post Doc – Drug Discovery & Pre-Clinical/Clinical Development

Job Category

Career Program

All Job Posting Locations

Beerse, Antwerp, Belgium

Job Description

We are currently recruiting for a Postdoc on cofolding models for In-Silico Drug Discovery based in Beerse, Belgium.

We are seeking a Postdoctoral Scholar to join our cutting‑edge In Silico Discovery department within Therapeutics Discovery at J&J. This position is intended for early‑career scientists with strong technical training and research interest in co‑folding models, structural bioinformatics, and AI/ML for drug discovery.

The position focuses on research and development of fine‑tuning strategies for co‑folding models applied to structure‑based drug discovery. The role will involve generating and curating training and benchmarking datasets, evaluating task‑specific performance, and integrating fine‑tuned models into discovery workflows. The Postdoctoral Scholar will work closely with computational scientists in a collaborative, multidisciplinary research environment.

Responsibilities Of The Postdoctoral Scholar Will Include

• Design, run, and analyze fine‑tuning experiments for co‑folding and structure‑prediction models, including benchmarking against internal and external baselines.
• Generate, curate, and manage training and validation datasets (e.g. complex structures, MD‑derived conformational ensembles, and project‑specific data) to support model fine‑tuning and evaluation
• Assess model performance using appropriate structural and task‑relevant metrics and contribute to best practices for model evaluation
• Integrate fine‑tuned co‑folding models into end‑to‑end discovery workflows, including inference, reporting, and documentation
• Collaborate closely with In Silico Discovery scientists across CADD, biologics, and AI/ML teams to align research outputs with drug‑discovery needs
• Contribute to internal scientific communication, documentation, and publication‑ready summaries of research outcomes
• Participate in external collaborations and consortia related to co‑folding and structural biology AI, supporting integration of research deliverables
• Engage in professional development through training courses, conferences, and internal scientific meetings as aligned with project milestones

Required

• PhD in computational chemistry, structural bioinformatics, computational biology, or machine learning applied to biomolecular systems.
• Strong understanding of protein structure and structure‑based modeling concepts.
• Experience with AI/ML model development, training, fine‑tuning, and evaluation (e.g. PyTorch or similar frameworks).
• Experience generating or working with structural datasets (e.g. protein–ligand or protein–protein complexes, MD‑derived data).
• Experience coding and developing research workflows in Python
• Familiarity with HPC and GPU computing environments.
• Strong analytical, problem‑solving, and scientific communication skills.
• Track record of scientific deliveries, including peer reviewed first-author publications and presentations at major national meetings is required.
• Professional fluency in English.
• Up to 10% travel both domestically and internationally is required.

Preferred Skills

• Postdoctoral or doctoral research exposure to co‑folding models, structural AI, or related foundation models.
• Experience benchmarking ML models for scientific or drug‑discovery applications
• Familiarity with protein–ligand or antibody–antigen modeling, docking, and virtual screening concepts.
• Experience with reproducible research practices (version control, testing, documentation).
• Exposure to drug‑discovery workflows or collaboration with medicinal chemistry or biologics teams.
• Experience working within academic–industry research collaborations or consortia.
• Familiarity with co‑folding models or structure‑prediction approaches applied to biomolecular systems.

The Anticipated Base Pay Range For This Position Is

€60.000,00 - €96.255,00

Benefits

In addition to base pay, we offer the following benefits*: an annual bonus with set target (% of pay) depending on pay grade / location, where the actual amount is based on the employees’ and companies’ performance of the previous calendar year, or sales commissions. Moreover, we offer vacation days, parental leave for a minimum of 12 weeks, bereavement leave, caregiver leave, volunteer leave, well-being reimbursement, programs for financial, physical and mental health. We also offer service anniversary and recognition awards, and subject to the terms of their respective plans, employees - and in some location’s eligible dependents - can participate in several insurance plans. For more information, visit Employee benefits | Supporting well-being & career growth | Johnson & Johnson Careers.

• This is for informative purposes only. Amounts and actual benefits may vary by location and are subject to change.