MRI Scientist

Actalent; Beerse; Sur place; EUR 70 000 - 90 000; Plein temps

Résumé du poste

Actalent in Beerse, Belgium, seeks an MRI Scientist to develop and validate MRI methods for pharmaceutical materials, formulations and drug-delivery devices. The role involves creating MRI workflows that complement CT analysis and address water ingress, hydration kinetics, coating performance and internal movement within devices.

You will translate imaging data into actionable insights for formulation and process teams, support cross-functional studies, and help build SOPs and data

Qualifications

• Master’s degree in physics, Chemistry or related field; PhD advantageous but not required.
• Hands‑on experience with pre‑clinical MRI instrumentation
• Experience interpreting imaging and spectroscopic data and communicating results to a non‑expert audience.
• Experience with solid state NMR is a plus
• Knowledgeable in organic chemistry is a plus

Responsabilités

• Develop and validate MRI methods for pharmaceutical materials, formulations, and dosage forms.
• Establish MRI workflows complementary to CT scan analysis for typical pharmaceutical applications like water ingress, hydration kinetics, disintegration, swelling, diffusion and dissolution.
• Assess coating integrity, permeability, delayed-release behaviour and capsule disintegration in complex dosage forms.
• Characterize device functionality for drug-delivery systems with MRI visualization of internal movement and fluid distribution.
• Monitor sedimentation and resuspendability of suspensions and depots, and interpret data for project teams.

Description du poste

For our client based in Beerse (Belgium), we are looking for a MRI Scientist to find innovative solutions for the development of MRI methods for active pharmaceutical ingredients (API), drug product in complex formulations and device functionality for drug-delivery systems.

Responsibilities

• Develop and validate MRI methods for pharmaceutical materials, formulations, and dosage forms.
• Establish MRI workflows complementary to CT scan analysis for typical pharmaceutical applications like:
• Water ingress and hydration kinetics in tablets, capsules, gels, and complex dosage forms to understand disintegration, swelling, diffusion, and dissolution-related mechanisms.
• Coating and capsule performance, including assessment of coating integrity, permeability, delayed-release behaviour, capsule disintegration, and spatial heterogeneity of release-controlling films.
• Device functionality for drug-delivery systems where MRI can support non-destructive visualization of internal movement, fluid distribution, filling/emptying behaviour, and functional performance under relevant test conditions.
• Sedimentation and resuspendability of suspensions, depots, and dispersed systems by monitoring particle settling, phase separation, redistribution after agitation.

• Translate imaging data into actionable formulation and process insights for project teams.
• Support cross-functional studies involving formulation development, analytical development, material science, and product performance assessment.
• Build internal expertise, standard operating procedures, and fit-for-purpose data interpretation practices for MRI-based characterization.
• Potentially perform basic solid-state NMR experiments.

Must-haves

• A minimum of master’s degree in physics, Chemistry or related field, with an affinity to complex instrumentation. A Ph.D. in one of these fields is advantageous, but not required.
• Hands‑on experience with pre‑clinical MRI Instrumentation is mandatory
• Experience with interpreting imaging and spectroscopic data and communicating results to a non‑expert audience.
• Experience with solid state NMR is a plus
• Knowledgeable in organic chemistry is a plus

Location: Beerse, Belgium

Contract Type: 12 months

Start Date: ASAP

While we appreciate every application, please note that due to the high volume of responses, we may only be able to contact shortlisted candidates.