Cell Line & Upstream Process Development Engineer

simAbs; Winterslag; Sur place; EUR 60 000 - 80 000; Plein temps

Résumé du poste

A biotechnology firm in Belgium is seeking a Process Development Engineer specializing in Cell Line Development and Upstream Process Development. The successful candidate will play a crucial role in developing mammalian cell lines and processes for biologics manufacturing, ensuring compliance with GMP standards. Responsibilities include designing strategies for cell line generation and optimizing processes in bioreactors. A Master’s or PhD in a relevant field and experience in regulated environments are essential qualifications.

Qualifications

• Proven experience in cell line development and/or upstream process development.
• Hands-on experience with cell culture techniques and bioreactor systems.
• Experience in a regulated GMP environment is a strong asset.

Responsabilités

• Design, execute, and optimize strategies for mammalian cell line generation.
• Develop and optimize upstream processes in shake flasks and bioreactors.
• Support technology transfer of upstream processes to GMP manufacturing.

Connaissances

Cell culture techniques

Bioreactor systems

Data analysis

Problem-solving skills

Communication skills

Formation

Master’s or PhD degree in Biotechnology or related field

Description du poste

About The Job

As a Process Development Engineer Cell Line Development & Upstream Process Development, you will play a key role in the development of robust, scalable mammalian cell lines and upstream processes to support biologics manufacturing. You will work in a multidisciplinary team at the interface of research, process development, and GMP manufacturing, contributing directly to the successful transfer of processes toward clinical and commercial production.

Your expertise will help establish and optimize cell culture processes while ensuring scientific rigor, reproducibility, and readiness for future GMP implementation.

Responsibilities

Cell Line Development

• Design, execute, and optimize strategies for mammalian cell line generation, screening, and selection.
• Perform clone evaluation based on productivity, stability, growth, and product quality attributes.
• Maintain detailed experimental documentation and ensure data integrity.
• Support scale-down models representative of GMP manufacturing processes.

Upstream Process Development

• Develop and optimize upstream processes in shake flasks and bioreactors.
• Evaluate media, feeds, and process parameters to improve productivity and robustness.
• Analyze process data and translate results into scalable and transferable process knowledge.
• Support technology transfer of upstream processes to GMP manufacturing or external partners.
• Collaborate closely with downstream process development, analytical development, quality, and manufacturing teams.
• Contribute to development reports, process descriptions, and technical documentation.
• Support risk assessments, process characterization, and comparability studies.
• Ensure compliance with data integrity principles and, where applicable, GMP expectations.

Vereisten

• A Master’s or PhD degree in Biotechnology, Biochemistry, Cell Biology, Bioprocess Engineering, or a related field.
• Proven experience in cell line development and/or upstream process development for mammalian cell culture.
• Hands‑on experience with cell culture techniques and bioreactor systems.
• Strong scientific mindset with excellent data analysis and problem‑solving skills.
• Experience working in a regulated (GMP or GMP‑adjacent) environment is a strong asset.
• Well‑organized, detail‑oriented, and capable of managing multiple development activities in parallel.
• A proactive, collaborative, and results‑driven attitude.
• Strong communication skills, both written and verbal.
• Flexibility and adaptability within a dynamic, fast‑growing environment.
• A start‑up mentality with a willingness to take ownership and drive innovation.