PhD Candidate - Immunogenomics of Arthritic Joint Disease

Garvan Institute of Medical Research; Sydney; On-site; AUD 34,000 - 46,000; Full time

Job summary

The Garvan Institute of Medical Research invites applications for a PhD candidate position in Immunogenomics of Arthritic Joint Disease. The role involves analyzing cutting-edge genomic data and collaborating across the Garvan and Broad Institute to advance arthritis research.

You will work with single-cell, long-read sequencing datasets and develop analytical pipelines to understand disease mechanisms and identify potential drug targets, contributing to a translational pipeline for novel

Qualifications

• Domestic candidates only.
• 3.5-year stipend of 39,991 AUD per annum (2027 rate).
• Global Mobility Grant of 25,000 AUD (one-off).
• Applications must include CV, transcripts, and cover letter.

Responsibilities

• Travel between Garvan Institute and Broad Institute in Cambridge.
• Analyze the world’s first single-cell, long-read sequencing data in diseased arthritic joints.
• Contribute to pipeline for producing and pre-clinically testing arthritis therapies.

Skills

Genomic analysis

Single-cell sequencing

Long-read sequencing

Data pipelines

Job description

PhD Candidate - Immunogenomics of Arthritic Joint Disease

Garvan Institute of Medical Research - Sydney CBD NSW

Immunogenomics of Arthritic Joint Disease

Our top PhD candidate will travel between the Garvan Institute, and Broad Institute of MIT and Harvard, in Cambridge.

You will apply genomic technologies and analytical pipelines uniquely available at Broad, to the fastest growing Arthritis Tissue Biobank in Australia, within Garvan's Masle-Farquhar Lab.

Arthritis affects 3.7 million Australians, causing ongoing pain, disability, isolation, comorbidities and premature deaths. Treatments are trial-and-error; only ~20% of rheumatoid or psoriatic arthritis patients reach remission. Osteoarthritis has no approved disease-modifying drug.

You will analyse the world's first single-cell, long-read sequencing dataset integrating transcriptome, clonotypes, isoforms and acquired mutations - directly within diseased arthritic joints. And access other unique datasets, including large-scale single-cell genetics analyses of hundreds of patients.

Your insights into disease mechanisms, treatment resistance, and novel drug targets will directly feed our established pipeline for producing and pre-clinically testing novel arthritis therapies.

Scholarship value

$39,991 per annum (2027 rate) stipend for 3.5 years
$25,000 Global Mobility Grant (one-off)

Candidates must be domestic. Applications close 11th of November. We will review applications as soon as they arrive.

Applications must include CV, transcripts, and thoughtful, detailed and original cover letter.