Advanced Research Scientist: MRD cfDNA & NGS Methods

One Nucleus; Town Of Cambridge; On-site; AUD 90,000 - 130,000; Full time

Job summary

NeoGenomics is seeking a Scientist II, Advanced Research to advance a novel MRD detection method from early research through optimization and viability assessment. The role is hands-on, requiring expertise in NGS library preparation, cfDNA workflows, and close collaboration with computational colleagues to translate method requirements into analytical specs.

The candidate will troubleshoot discrepancies between wet lab and computational results, maintain rigorous experimental records, and

Qualifications

• Hands-on next generation sequencing library preparation is essential.
• Experience with cell-free DNA, low input library preparation, UMI sequencing, or other error suppression approaches is strongly preferred.
• Experience in cancer diagnostics, liquid biopsy or ctDNA analysis preferred.
• Strong practical laboratory skills in NGS library construction and quantitative molecular biology.
• Working knowledge of cancer biology and cancer genomics.
• Ability to troubleshoot complex experimental systems and identify sources of error.
• Experience handling human clinical samples with governance awareness.
• Excellent written and verbal communication and ability to present data clearly.

Responsibilities

• Refine and execute program of research and optimization experiments for a novel cell free DNA MRD detection method.
• Independently perform complex and novel library preparation and next generation sequencing workflows.
• Perform supporting work such as blood processing and cfDNA extractions.
• Diagnose and resolve experimental problems and elevate appropriately.
• Analyze and interpret sequencing data in collaboration with computational colleagues.
• Maintain complete experimental records suitable for regulatory and patent purposes.
• Present data and recommendations clearly to the team and senior leadership.
• Work with internal/external teams to obtain contrived or clinical samples.

Skills

NGS library prep

Cell-free DNA

UMI sequencing

Experimental design

Troubleshooting

Education

Ph.D. in Genetics/Genomics/Molecular Biology/Biochemistry

MS with 10+ years

BS with 14+ years

Job description

NeoGenomics is seeking a Scientist II, Advanced Research to advance a novel MRD detection method from early research through optimization and viability assessment. The role is hands-on, requiring expertise in NGS library preparation, cfDNA workflows, and close collaboration with computational colleagues to translate method requirements into analytical specs.

The candidate will troubleshoot discrepancies between wet lab and computational results, maintain rigorous experimental records, and