Paid Diploma / Master's Thesis - Modeling and process control for a continuous biopharmaceutica[...]

Research Center Pharmaceutical Engineering GmbH; Österreich; Vor Ort; EUR 8.900 - 13.000; Vollzeit

Benefits dieser Stelle

Paid opportunity

Research experience

Zusammenfassung

A leading research center in the pharmaceutical sector in Graz, Austria, offers a paid Diploma/Master's thesis opportunity focused on enhancing sustainability in biopharmaceutical manufacturing. The project emphasizes the development of process models and model-based control algorithms for unit operations such as chromatography. Candidates will engage in innovative research, contributing to the efficiency of biopharmaceutical processes. This is an excellent opportunity for students aiming to apply their knowledge in a meaningful way.

Aufgaben

• Focus on improving sustainability in biopharmaceutical manufacturing.
• Develop process models for simulation-based development.
• Evaluate control algorithms for biopharmaceutical processes.

Jobbeschreibung

Paid Diploma / Master's Thesis

OBJECTIVE

The focus of this thesis is on improving the sustainability of a biopharmaceutical manufacturing line. This should be achieved by applying feedback control concepts and manipulating the process parameters of the selected unit operations, e.g., of a perfusion bioreactor, or multiple filtration and chromatography units.

Process models enabling simulation based development and model-based control algorithms are required. Computationally efficient dynamic models, focusing on the parameters relevant for the developed control concepts will be developed and evaluated for this purpose.

POSSIBLE TOPICS ARE

• Development and implementation of a process model for a biopharmaceutical unit operation (e.g., chromatography)
• Development of suitable model-based control algorithms for specified units