Senior Process Development Engineer - Biologics (Remote)

Placements24; Stellenbosch; Remote; ZAR 900,000 - 1,200,000; Full time

Job summary

Placements24 seeks a Senior Process Development Engineer for a fully remote role focused on designing, optimizing, and scaling bioprocesses for biologics from a home office. The candidate will drive robust, efficient, and reproducible manufacturing processes using advanced analytics and asynchronous collaboration.

You will lead upstream and downstream development, scale-up activities, and support technology transfer in a remote-first environment with Paarl oversight in SA.

Qualifications

• Advanced bioprocess development knowledge is required.
• Experience in upstream and downstream bioprocessing.
• Strong analytical and problem-solving skills.

Responsibilities

• Develop and optimize upstream and downstream bioprocesses for biologics (e.g., mAbs, recombinant proteins).
• Design and execute experiments to understand process parameters, identify CPCs, and establish design space.
• Scale-up processes from lab to pilot and commercial scales with robust process control.
• Troubleshoot deviations and implement corrective and preventive actions (CAPA).
• Utilize PAT and statistical tools for monitoring and control.
• Author development reports and technology transfer documentation.

Skills

Bioprocess development

Scale-up

DOE

PAT

Process analytics

Troubleshooting

MAbs

Tools

PAT tools

DOE software

Job description

About the Role

Our client, a leader in the development and manufacturing of advanced biologics, is seeking a highly skilled Senior Process Development Engineer. This is a critical, fully remote role focused on designing, optimizing, and scaling up bioprocesses for therapeutic proteins and other biological products. You will be at the forefront of innovation, applying your expertise to ensure robust, efficient, and reproducible manufacturing processes. As a remote-first company, we champion asynchronous communication, advanced collaboration tools, and a culture of trust and autonomy, ensuring our remote team members are fully integrated and productive. This position offers an exceptional opportunity to contribute to the production of life-saving therapies from your home office. Your technical prowess will be key to our success. The Paarl vicinity is noted for administrative oversight within our client's South African structure, though your role will be performed entirely remotely.

Key Responsibilities

• Develop and optimize upstream and downstream bioprocesses for the manufacture of biologics (e.g., mAbs, recombinant proteins).
• Design and execute experiments to understand process parameters, identify critical process controls (CPCs), and establish process design space.
• Scale-up processes from laboratory to pilot and commercial manufacturing scales, ensuring process robustness and consistency.
• Troubleshoot process deviations and implement effective corrective and preventive actions.
• Utilize Process Analytical Technology (PAT) and statistical tools for process monitoring and control.
• Author development reports, technology