Senior Pharmaceutical Development Chemist

Placements24; Mossel Bay; Hybrid; ZAR 900,000 - 1,300,000; Full time

Benefits offered by this job

Remote-first culture

Competitive salary and benefits

Technology stipend for home office

Professional development opportunities

Job summary

Placements24 invites applications for a Senior Pharmaceutical Development Chemist in a remote role. You will drive synthesis, purification, and characterization of APIs and intermediates, scaling up routes for clinical and commercial supply, and collaborating with R&D teams worldwide.

The ideal candidate holds a PhD in Organic or Medicinal Chemistry with 5+ years in pharma development, strong analytical skills (NMR, MS, HPLC, IR), and proven ability to work independently in a remote environment

Qualifications

• Ph.D. in Organic or Medicinal Chemistry required.
• Minimum 5 years of post-doctoral or industry experience in pharmaceutical development.
• Extensive experience with multi-step organic synthesis and purification techniques.
• Proficiency in NMR, MS, HPLC, and IR spectroscopic methods.
• Strong problem-solving and communication skills; able to work independently in a remote environment.

Responsibilities

• Design and optimize synthetic routes for APIs and intermediates.
• Scale-up processes for clinical and commercial supply.
• Develop and validate analytical methods for materials and products.
• Maintain thorough lab records and ensure GLP compliance.
• Collaborate with process engineers for pilot and commercial manufacturing parameters.
• Stay current with advances in synthetic organic chemistry and pharma development.

Skills

Problem solving

Communication

Independent worker

Education

PhD in Organic/Medicinal Chemistry

Tools

NMR

MS

HPLC

IR spectroscopy

Job description

About the Role

This is an exciting opportunity to join Our client, a leading pharmaceutical company, in a fully remote Senior Pharmaceutical Development Chemist role. We are seeking a highly skilled and motivated individual to contribute to our drug development programs. You will play a critical role in the synthesis, purification, and characterization of active pharmaceutical ingredients (APIs) and intermediates. Your expertise in organic chemistry and process development will be essential in scaling up synthetic routes for clinical and commercial supply. As a remote team member, you will work independently and collaboratively with our research and development teams, utilizing advanced tools and technologies to drive innovation. This position offers the chance to make a tangible impact on the development of new medicines from the comfort of your own home office. Our client is committed to fostering a remote-first culture, providing the necessary support and resources for you to excel in this challenging and rewarding role. Your contributions will be vital in advancing our pipeline and bringing new therapies to patients worldwide.

Key Responsibilities

• Design and execute synthetic routes for the preparation of APIs and key intermediates.
• Optimize chemical processes for yield, purity, and scalability.
• Perform in-depth characterization of synthesized compounds using techniques such as NMR, MS, HPLC, and IR spectroscopy.
• Develop and validate analytical methods for raw materials, in-process controls, and finished products.
• Troubleshoot synthetic and analytical challenges.
• Collaborate with process engineers to define parameters for pilot and commercial scale manufacturing.
• Maintain accurate and comprehensive laboratory notebooks and reports.
• Ensure compliance with safety, environmental, and Good Laboratory Practices (GLP).
• Stay current with advancements in synthetic organic chemistry and pharmaceutical development.
• Contribute to the intellectual property portfolio through invention disclosures.

Requirements

• Ph.D. in Organic Chemistry, Medicinal Chemistry, or a related field.
• Minimum of 5 years of post-doctoral or industry experience in pharmaceutical chemical development.
• Extensive experience in multi-step organic synthesis and purification techniques.
• Proficiency in modern spectroscopic and chromatographic analytical techniques.
• Strong understanding of process chemistry and scale-up principles.
• Experience with regulatory requirements for API development (e.g., ICH guidelines).
• Excellent problem-solving and critical thinking abilities.
• Strong written and verbal communication skills.
• Ability to work independently and manage time effectively in a remote environment.
• Demonstrated ability to document research findings meticulously.

Benefits

• Our client offers a competitive salary, commensurate with experience, and a comprehensive remote work benefits package.
• This includes health, dental, and vision insurance, a retirement savings plan with company matching, and generous paid time off.
• We provide a technology stipend to ensure you have the best equipment for your home office.
• Opportunities for professional development, including online courses and virtual conferences, are readily available.
• You'll be part of an innovative and collaborative global team, contributing to significant advancements in medicine from your remote location near Mossel Bay, Western Cape .
• Our client values its remote employees and provides a supportive and engaging virtual work culture.