Senior Clinical Research Associate (CRA) - Oncology

Placements24; South Africa; On-site; ZAR 900,000 - 1,200,000; Full time

Benefits offered by this job

Health insurance

Retirement plan

Paid time off

Career development

Job summary

Placements24 is seeking an experienced Senior Clinical Research Associate to join a global oncology team in Pretoria, Gauteng. The role focuses on site monitoring, SDV, and ensuring GCP and regulatory compliance across multiple trials.

The ideal candidate has 5+ years of CRA experience in oncology, strong data integrity skills, and the ability to travel to trial sites as required. Join a leading pharmaceutical company committed to advancing cancer therapies.

Qualifications

• Bachelor's degree in a life science, nursing, or related field.
• Minimum 5 years of direct CRA experience with oncology trials.
• Solid knowledge of GCP, ICH guidelines and regulatory requirements.

Responsibilities

• Conduct pre-study, initiation, routine monitoring, and close-out visits per protocol and GCP.
• Verify data integrity via source data verification (SDV).
• Ensure investigational product accountability and proper site handling.
• Manage site-level activities and train site staff as needed.
• Identify deviations and implement corrective actions.
• Oversee site regulatory compliance and documentation.
• Communicate with project teams (PMs, data managers, monitors).
• Contribute to study documents (protocols, CRFs, monitoring plans).
• Participate in Investigator Meetings and train new CRAs.

Skills

GCP knowledge

Site monitoring

SDV

CTMS

EDC

Oncology trials

Travel readiness

Regulatory understanding

Education

Bachelor's degree life science

Nursing

Tools

CTMS

EDC

Job description

About the Role

Our client, a renowned global pharmaceutical company with a strong focus on oncology research, is looking for an experienced Senior Clinical Research Associate (CRA) to join their expanding team in Pretoria, Gauteng. This critical role involves overseeing and managing clinical trial sites to ensure the efficient and accurate execution of oncology studies. The Senior CRA will be responsible for monitoring study progress, ensuring adherence to protocols, regulatory requirements, and Good Clinical Practices (GCP). You will play a vital part in bringing life‑saving cancer treatments to patients by ensuring the integrity and quality of clinical trial data. This is an exciting opportunity to work on cutting‑edge oncology trials and collaborate with leading investigators and healthcare professionals. We seek a highly organized, detail‑oriented professional with a passion for clinical research and improving patient outcomes. The Pretoria, Gauteng location offers a central hub for professional engagement.

Key Responsibilities

• Conduct pre-study, initiation, routine monitoring, and close‑out visits to clinical trial sites according to protocol, GCP, and regulatory requirements.
• Verify the accuracy, completeness, and integrity of clinical trial data through source data verification (SDV).
• Ensure investigational product accountability and proper handling at the site.
• Manage site‑level activities, build strong relationships with investigators and site staff, and provide ongoing training and support.
• Identify, document, and report site deviations and ensure timely implementation of corrective actions.
• Oversee regulatory compliance at the site level, ensuring all necessary documentation is complete and current.
• Communicate effectively with internal project teams, including project managers, data managers, and medical monitors.
• Contribute to the development and finalization of study‑related documents, such as protocols, case report forms (CRFs), and monitoring plans.
• Participate in Investigator Meetings and provide training to new CRAs as needed.

Requirements

• Bachelor's degree in a life science, nursing, or related field.
• Minimum of 5 years of direct experience as a Clinical Research Associate, with a significant portion focused on oncology trials.
• In‑depth knowledge of GCP, ICH guidelines, and relevant regulatory requirements for clinical trials.
• Proven experience in site monitoring, SDV, and ensuring data integrity.
• Excellent understanding of oncology clinical trial processes and therapeutic areas.
• Strong communication, interpersonal, and organizational skills.
• Ability to travel frequently to clinical trial sites as required.
• Proficiency in clinical trial management systems (CTMS) and electronic data capture (EDC) systems.
• Demonstrated ability to work independently and manage workload effectively.

Benefits

Our client offers a competitive salary, performance‑based incentives, and a comprehensive benefits package including health insurance, retirement contributions, and generous paid time off. We invest in our employees' professional development, offering opportunities for specialized training and career advancement. This role provides the chance to make a real difference in the fight against cancer. Based in Pretoria, Gauteng, this position is ideal for professionals seeking a challenging and rewarding career in pharmaceutical research. Join a company that values your expertise and dedication to improving patient lives through innovative oncology treatments.