Senior Clinical Data Manager

ICON Clinical Research; Johannesburg; On-site; ZAR 900,000 - 1,300,000; Full time

Benefits offered by this job

Annual leave

Health insurance

Retirement plan

Employee assistance program (LifeWorks

Life assurance

Childcare vouchers

Job summary

ICON Strategic Solutions seeks a Senior Clinical Data Manager to act as the primary data lead across global trials, delivering regulatory-compliant data from start-up to database lock. You will drive EDC builds, system integrations, and data deliverables while overseeing data review and vendor management.

The role requires leading studies across the full lifecycle, strong CDISC/SDTM knowledge, and excellent communication and leadership skills to partner with sponsors and cross-functional teams.

Qualifications

• Bachelor's degree in Life Sciences, Health Sciences, or related discipline.
• 6+ years of Clinical Data Management or Clinical Data Science in CRO/pharma.
• Experience leading studies across full clinical trial lifecycle.
• Proven data lead on complex studies with hands-on data review across EDC, vendor, eCOA, IRT, SAE data.
• Strong vendor oversight, stakeholder management, and knowledge of CDISC standards (SDTM).

Responsibilities

• Act as the primary data lead within cross-functional study teams and sponsor partnerships.
• Drive study start-up activities including EDC build, system integrations, UAT, and data management deliverables.
• Oversee data review, reconciliation, vendor management, and database lock activities.
• Ensure compliance with CDISC standards, ICH-GCP requirements, and regulatory expectations.
• Identify and mitigate risks while driving continuous improvement and operational excellence.

Skills

Data lead leadership

EDC systems

Vendor oversight

CDISC SDTM

ICH-GCP knowledge

Communication skills

Education

Bachelor's degree in Life Sciences/Health Sciences

Tools

Veeva EDC

Job description

Senior Clinical Data Manager

At ICON Strategic Solutions, you will work in a sponsor-dedicated model, supported by ICON's global expertise.

As the world’s largest FSP organisation, with over 90 sponsor partnerships, we offer stability, career development and a collaborative environment where your work contributes to the development of treatments that benefit patients worldwide.

As a Clinical Data Manager at ICON, you will be client dedicated, serving as the primary data lead across global clinical trials and partnering closely with sponsors to drive high-quality, regulatory-compliant data delivery from study start-up through database lock.

Key responsibilities

• Acting as the primary data lead within cross-functional study teams and sponsor partnerships
• Driving study start-up activities including EDC build, system integrations, UAT, and key data management deliverables
• Overseeing data review, reconciliation, vendor management, and database lock activities
• Ensuring compliance with CDISC standards, ICH-GCP requirements, and regulatory expectations
• Identifying and mitigating risks while driving continuous improvement and operational excellence

You will Have/Be:

• Bachelor's degree in Life Sciences, Health Sciences, or a related discipline
• 6+ years of Clinical Data Management or Clinical Data Science experience within a CRO or pharmaceutical environment
• Proven experience leading studies across the full clinical trial lifecycle
• Experience as a primary Data Lead on complex studies and/or extensive hands-on data review and reconciliation experience across EDC, vendor, eCOA, IRT, and SAE data
• Strong vendor oversight and stakeholder management experience
• Hands-on experience with EDC systems, with Veeva EDC preferred
• Knowledge of CDISC standards, including SDTM
• Strong understanding of clinical trial processes, regulatory requirements, and ICH-GCP
• Excellent communication, problem-solving, and project leadership skills

What ICON can offer you:

Our success depends on the quality of our people. That’s why we’ve made it a priority to build a diverse culture that rewards high performance and nurtures talent.

In addition to your competitive salary, ICON offers a range of additional benefits. Our benefits are designed to be competitive within each country and are focused on well‑being and work life balance opportunities for you and your family.

Our benefits examples include:

• Various annual leave entitlements
• A range of health insurance offerings to suit you and your family's needs.
• Competitive retirement planning offerings to maximize savings and plan with confidence for the years ahead.
• Global Employee Assistance Programme, LifeWorks, offering 24-hour access to a global network of over 80,000 independent specialized professionals who are there to support you and your family's well‑being.
• Life assurance
• Flexible country‑specific optional benefits, including childcare vouchers, bike purchase schemes, discounted gym memberships, subsidized travel passes, health assessments, among others.

Visit our careers site (https://careers.iconplc.com/benefits) to read more about the benefits ICON offers.

At ICON, inclusion & belonging are fundamental to our culture and values. We're dedicated to providing an inclusive and accessible environment for all candidates. ICON is committed to providing a workplace free of discrimination and harassment. All qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please let us know or submit a request here (https://careers.iconplc.com/reasonable-accommodations)