Senior Biophysicist & Team Lead — Drug Discovery

Placements24; Kempton Park; Sur place; ZAR 1 000 000 - 1 700 000; Plein temps

Avantages offerts par ce poste

Competitive salary

Bonus structure

Health, dental, vision insurance

Retirement plan with employer matching

Conference funding

Relocation assistance

Résumé du poste

Placements24 in Tembisa, Gauteng seeks a Lead Biophysicist to spearhead biophysics for drug discovery. You will lead a team, design and execute experiments using SPR, ITC, MST, DLS, and thermal shift assays, while collaborating with cross-functional teams to drive programs forward.

The role combines hands-on science with strategic leadership, enabling the development of novel therapeutics and ensuring data integrity and safety across all activities.

Qualifications

• Ph.D. in biophysics/biochemistry/molecular biology or related discipline.
• 7+ years research experience with at least 3 years in a leadership role.
• Hands-on label-free interaction analysis (SPR, BLI, ITC) expertise.
• Strong knowledge of protein expression, purification and characterization.
• Experience with structural biology techniques is a plus.

Responsabilités

• Provide scientific direction and mentorship to the biophysics team.
• Design, optimize and implement biophysical techniques (SPR, ITC, MST, DLS, thermal shift).
• Investigate protein–ligand interactions, binding kinetics, thermodynamics, and conformational changes.
• Analyze and interpret complex biophysical data, generating high-quality reports.
• Collaborate with medicinal chemistry, structural biology and pharmacology teams to advance drug discovery.
• Develop and validate new biophysical assays for screening and characterization of drug candidates.
• Contribute to strategic planning of research programs and identify new therapeutic targets.
• Ensure the highest standards of scientific rigor, data integrity, and laboratory safety.

Connaissances

Leadership

Scientific communication

Data analysis

Project management

Problem-solving

Formation

Ph.D. in Biophysics/Biochemistry/Molecular Biology

Outils

SPR

ITC

BLI

DLS

Thermal Shift

Description du poste

Placements24 in Tembisa, Gauteng seeks a Lead Biophysicist to spearhead biophysics for drug discovery. You will lead a team, design and execute experiments using SPR, ITC, MST, DLS, and thermal shift assays, while collaborating with cross-functional teams to drive programs forward.

The role combines hands-on science with strategic leadership, enabling the development of novel therapeutics and ensuring data integrity and safety across all activities.