Principal Statistical Programmer (SAS + R) – Remote

Curro Holdings Ltd; Cape Town; Remote; ZAR 1,200,000 - 1,700,000; Full time

Job summary

Cytel Inc. is seeking a Senior/Principal Statistical Programmer (SAS + R) to work remotely with a sponsor-dedicated global pharmaceutical client. The role emphasizes independent work, leadership, and delivering high-quality programming for regulatory submissions.

The candidate will generate SDTM/ADaM specifications, develop complex SAS programs, and oversee CRO deliverables across multiple studies, ensuring timely, compliant data outputs and collaboration with cross-functional teams.

Qualifications

• Bachelor’s degree in CS/Data Science/Math/Statistics preferred.
• 7+ years as Statistical Programmer in Biotech/Pharma Clinical Development Biometrics Team.
• Exceptional SAS programming skills in a clinical development environment.
• Extensive CDISC standards (SDTM, ADaM, Define.xml) experience.
• Experience supporting regulatory submissions with FDA/global authorities.
• Ability to work independently.
• Strong written and verbal communication and leadership.

Responsibilities

• Generate SDTM, ADaM specifications, datasets, reviewer’s guide and Define.xml files for multiple studies.
• Develop SAS programs to generate datasets, listings, tables, and graphs.
• Deliver high-quality SAS/R programs for clinical development programs.
• Oversee CROs’ programming deliverables to meet timelines.
• Support preparation of clinical study reports and regulatory submissions.
• Ensure FDA regulations and GCP for submissions are followed.
• Contribute to standards for programming tools, outputs, and macros.
• Develop CRFs, edit check specs, and data validation plans.
• Provide data transfer specifications for external vendors.
• Collaborate with CROs, vendors and partners to meet timelines.
• Review and author SOPs and Work Instructions.

Skills

SAS programming

CDISC SDTM/ADaM

Regulatory submissions

Independent work

Leadership

Communication skills

Education

Bachelor’s degree in Computer Science / Data Science / Mathematics / Statistics

Tools

R

Python

Unix/Linux

Git

Shiny

Job description

Cytel Inc. is seeking a Senior/Principal Statistical Programmer (SAS + R) to work remotely with a sponsor-dedicated global pharmaceutical client. The role emphasizes independent work, leadership, and delivering high-quality programming for regulatory submissions.

The candidate will generate SDTM/ADaM specifications, develop complex SAS programs, and oversee CRO deliverables across multiple studies, ensuring timely, compliant data outputs and collaboration with cross-functional teams.