About the Role
Our client, a leading pharmaceutical research institution, is seeking an exceptional Principal Research Scientist specializing in Immunology to join their state-of-the-art facility in Centurion, Gauteng, ZA . This senior leadership role is responsible for directing and executing innovative research programs focused on understanding immune system mechanisms and developing novel immunotherapies for a range of diseases. You will be at the forefront of scientific discovery, leading a team of talented researchers, designing complex experimental strategies, and interpreting critical data. The ideal candidate will possess a deep and broad knowledge of immunology, a strong publication record, and proven experience in managing research projects from inception to completion. This position requires a highly motivated individual with excellent leadership and communication skills, capable of fostering a collaborative and scientifically rigorous environment. The role is based on-site to facilitate hands-on laboratory work and seamless team collaboration within our dedicated research labs. We are committed to advancing human health through groundbreaking scientific research and development.
Key Responsibilities
- Lead the strategic direction and execution of immunology research programs, focusing on therapeutic targets and drug discovery.
- Design, implement, and oversee complex in vitro and in vivo immunological assays.
- Mentor and guide a team of research scientists and technicians, fostering scientific excellence and career development.
- Analyze and interpret complex experimental data, ensuring scientific rigor and robust conclusions.
- Develop and maintain cutting-edge knowledge of immunological pathways, disease mechanisms, and therapeutic approaches.
- Collaborate effectively with internal R&D teams (e.g., pharmacology, toxicology, DMPK) and external partners.
- Author high-impact publications in leading scientific journals and present findings at international conferences.
- Contribute to patent filings and regulatory submissions.
- Manage research budgets and resources efficiently.
- Ensure compliance with all laboratory safety regulations and ethical guidelines.
Requirements
- Ph.D. in Immunology, Molecular Biology, Cell Biology, or a related field.
- Minimum of 10 years of relevant post-doctoral research experience in immunology, with a significant portion in a drug discovery or development setting.
- Demonstrated track record of leadership in scientific research, with experience managing research teams.
- Extensive experience with a wide range of immunological techniques (e.g., flow cytometry, ELISpot, cytokine profiling, cell-based assays, immunology models).
- Strong understanding of innate and adaptive immunity, immune cell signaling, and immune-related diseases.
- Proven ability to develop novel research hypotheses and design experiments to test them.
- Excellent publication record in high-quality peer-reviewed journals.
- Exceptional communication, presentation, and interpersonal skills.
- Must be able to work full-time on-site at our facilities in Centurion, Gauteng, ZA .
- Experience in autoimmune diseases, oncology immunology, or infectious diseases is a plus.
Benefits
- Highly competitive salary package, reflecting seniority and experience.
- Attractive bonus structure and potential for equity.
- Comprehensive medical, dental, and vision insurance.
- Generous retirement savings plan with company match.
- Extensive paid time off, including holidays and personal leave.
- Opportunities for international conference travel and professional development.
- Access to state-of-the-art research facilities and equipment.
- Relocation assistance available for qualified candidates.
- On-site amenities such as a fitness center and cafeteria.
- A culture that values scientific curiosity and innovation.