Principal Genomics Computational Biologist - NGS & HPC Lead

Placements24; Mossel Bay; On-site; ZAR 1,800,000 - 2,400,000; Full time

Benefits offered by this job

Competitive salary

Health insurance

Retirement plan

Professional development

Job summary

Placements24, a leading genomics research entity, seeks a Principal Computational Biologist in Mossel Bay, Western Cape. You will lead projects analyzing large-scale genomic and transcriptomic datasets, developing cutting-edge bioinformatics pipelines for NGS data and collaborating with clinicians to translate findings into actionable insights.

The role requires a Ph.D. with 7+ years of post-doctoral genomics experience, proficiency in Python/R/Perl, and strong HPC/cloud skills.

Qualifications

• Ph.D. in Computational Biology, Genomics, or related field.
• 7+ years of post-doctoral research experience focusing on genomics/NGS data analysis.
• Experience with WGS, WES, RNA-Seq, ChIP-Seq.
• Proficiency in Python, R, or Perl and shell scripting.
• Experience with bioinformatics tools/databases: GATK, Samtools, BEDTools, Ensembl.
• Familiarity with HPC environments and cloud computing.
• Strong understanding of molecular biology, genetics, and statistics.
• Proven ability to lead research projects and mentor junior staff.
• Publications in high-impact journals is a plus.

Responsibilities

• Lead design and implementation of computational strategies for large-scale genomic datasets.
• Develop and maintain bioinformatics pipelines for NGS data processing.
• Analyze WGS, WES, RNA-Seq data and identify genetic variants.
• Collaborate with biologists to interpret results and design follow-up studies.
• Mentor junior computational biologists and bioinformaticians.
• Present findings at conferences and contribute to publications.
• Manage data resources ensuring data integrity, security, and accessibility.

Skills

Python

R

Perl

Shell scripting

Education

Ph.D. in Computational Biology

Tools

GATK

Samtools

BEDTools

Ensembl

HPC

Cloud

Job description

Placements24, a leading genomics research entity, seeks a Principal Computational Biologist in Mossel Bay, Western Cape. You will lead projects analyzing large-scale genomic and transcriptomic datasets, developing cutting-edge bioinformatics pipelines for NGS data and collaborating with clinicians to translate findings into actionable insights.

The role requires a Ph.D. with 7+ years of post-doctoral genomics experience, proficiency in Python/R/Perl, and strong HPC/cloud skills.