Lead Chemist - Pharmaceutical Synthesis

Placements24; George; On-site; ZAR 1,200,000 - 1,800,000; Full time

Job summary

Placements24 is seeking a dynamic Lead Chemist to head the Pharmaceutical Synthesis division in George. Lead organic synthesis, process chemistry, and analytical development within R&D, while mentoring chemists and delivering milestones in a state-of-the-art facility.

The role requires a PhD in Organic Chemistry with 7+ years in pharma R&D, and a strong track record in multi-step synthesis and scale-up. GMP compliance and leadership are essential.

Qualifications

• PhD in Organic Chemistry or closely related field.
• Minimum 7 years in pharma R&D with focus on synthesis and process chemistry.
• Experience in multi-step synthesis, scale-up, and reaction optimization.
• Strong analytical skills with spectroscopic and chromatographic techniques.
• Proven leadership and R&D team management.
• Knowledge of drug discovery and development processes.

Responsibilities

• Lead design and execution of synthetic routes for complex molecules.
• Develop scalable, efficient processes for manufacturing.
• Oversee analytical method development and validation (HPLC, GC-MS, NMR).
• Manage project timelines, resources, and budgets.
• Mentor a team of chemists and provide career development support.
• Ensure GMP-compliant laboratory practices and safety.

Skills

Organic synthesis

Process chemistry

Project management

Leadership

Analytical methods

Education

PhD in Organic Chemistry

Tools

HPLC

GC-MS

NMR

Job description

About the Role

Our client is seeking a dynamic and experienced Lead Chemist to spearhead their Pharmaceutical Synthesis division in George . This leadership role is crucial for driving innovation in the discovery and development of new drug candidates. You will be responsible for overseeing all aspects of organic synthesis, process chemistry, and analytical development within the R&D department. The ideal candidate will have a deep understanding of synthetic organic chemistry, a passion for problem-solving, and a strong ability to manage projects and mentor a team of chemists. This position offers a unique opportunity to contribute to groundbreaking pharmaceutical research in a state-of-the-art facility, shaping the future of medicine from our George location.

Key Responsibilities

• Lead the design and execution of synthetic routes for complex organic molecules and potential drug candidates.
• Develop and optimize scalable and efficient synthetic processes suitable for manufacturing.
• Oversee analytical method development and validation using techniques like HPLC, GC-MS, and NMR spectroscopy.
• Manage project timelines, resources, and budgets, ensuring timely delivery of research milestones.
• Mentor and supervise a team of research chemists, providing technical expertise and career development support.
• Ensure all laboratory activities adhere to stringent safety protocols and regulatory guidelines (e.g., GMP).

Requirements

• PhD in Organic Chemistry or a closely related field.
• A minimum of 7 years of experience in pharmaceutical research and development, with a focus on synthetic and process chemistry.
• Proven expertise in multi-step organic synthesis , reaction optimization, and scale-up.
• Strong analytical skills and hands-on experience with modern spectroscopic and chromatographic techniques.
• Demonstrated leadership capabilities and experience managing R&D teams.
• Excellent understanding of drug discovery and development processes.

Benefits

• An attractive annual salary with performance incentives.
• Comprehensive medical, dental, and vision coverage.
• Company-sponsored retirement savings plan.
• Generous professional development allowance for conferences and training.
• Access to advanced synthesis and analytical equipment in George .
• A stimulating work environment that encourages innovation and scientific rigor.