Diagnostic Product Production Analyst

National Bioproducts Institute; Durban; On-site; ZAR 300 000 - 450 000; Full time

Job summary

A leading manufacturer of therapeutic products seeks a Diagnostic Product Production Analyst in Durban. The candidate will conduct QC testing and manage productions related to monoclonal antibodies. Essential qualifications include a BSc in Biochemistry or Microbiology, along with relevant experience in ELISA and protein work. The role promises meaningful work in a vital therapeutic area.

Qualifications

• Essential: BSc in Biochemistry or Microbiology.
• Preferred: BSc Honours in Biochemistry or Microbiology.
• 2-3 years ELISA experience.
• 2-3 years recombinant protein expression and purification experience.

Responsibilities

• Conduct QC testing of MAT ELISA reagents and components.
• Perform method validations for internal programs.
• Complete documentation for final kits and upload results on SAP.
• Culture and purify recombinant proteins.
• Ensure compliance with ISO13485 standards.

Skills

ELISA experience

Recombinant protein expression

Protein purification

Education

BSc in Biochemistry

BSc Honours in Biochemistry

Tools

SAP

SDS-PAGE

Job description

Overview

Job title: Diagnostic Product Production Analyst

Job Location: KwaZulu-Natal, Durban

Deadline: October 27, 2025

Job Advert Summary

• Guided by its purpose to provide products for patients to alleviate pain and suffering and improve their quality of life, NBI’s vision is to be the leading African manufacturer and supplier of quality therapeutic proteins and diagnostic products.


• National Bioproducts Institute NPC has a vacancy for the role of Diagnostic Product Production Analyst . The successful incumbent will be required to :


• To use as an individual, his / her academic background, training and experience to perform immunoassay, protein expression and purifications prescribed for the production and QC analysis of saleable monoclonal antibodies, recombinant antigens, and MAT kit and components.


• Applications are invited from suitably qualified and experienced candidates.

Minimum Requirements

• Essential: BSc in Biochemistry, Microbiology


• Preferred: BSc Honours in Biochemistry, Microbiology


• 2-3 years ELISA experience


• 2-3 years recombinant protein expression and purification experience

Duties & Responsibilities

• QC testing of MAT ELISA reagents, components and final kits


• QC testing of final MAT kit


• Complete documentation for final kit and upload results on SAP


• Perform test and method validations according to internal DPP program


• Production and QC testing of recombinant antigens associated with saleable monoclonal antibodies and monoclonal antibodies


• Express and purify recombinant proteins to support monoclonal antibody production of saleable antibodies


• When required, assist with purifications of monoclonal antibodies for hybridoma and mAb validation projects


• QC testing to validate activity, specificity and coating concentration of produced recombinant antigens


• QC analysis of NBI saleable monoclonal antibodies


• Perform QC analysis on purified saleable monoclonal antibodies using sds-page gel electrophoresis and determine the antibody purity by densitometric analysis using gel imaging software


• Provide mAb purity and gel result documentation to Section Head : Antibody Production to complete final release of NBI monoclonal antibodies


• Execute activities of the Hybridoma laboratory when required


• Perform cell culture and injection duties of the Hybridoma Cell Biologist when required


• Culture specific monoclonal antibodies for research and commercial purposes


• Interprets and reports results to the Section Head : Antibody Production


• Laboratory resourcing and equipment maintenance


• Maintain laboratory equipment and cleanliness


• Maintain chemical and operational consumable stock levels


• Ensure compliance with ISO13485 standards


• Perform the general housekeeping of the laboratory


• Production / Manufacturing jobs