Bioprocess Fermentation Engineer - Hybrid, Scale-Up & GMP

Placements24

Benoni

Hybrid

ZAR 900,000 - 1,300,000

Full time

30 hours ago

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Benefits offered by this job

Competitive salary and benefits

Health benefits

Retirement planning

Professional development opportunities

Job summary

Placements24 is seeking a skilled Chemical Engineer with fermentation expertise to join our team in Benoni, SA. The role focuses on developing, optimizing, and scaling bioprocesses for high-value therapies.

You will collaborate with microbiologists, biochemists, and development scientists to advance projects from research through clinical production in a hybrid work model with on-site lab work and remote analysis.

Qualifications

Master's degree in Chemical Engineering with a specialization in biochemical engineering or bioprocess technology.
Minimum of 5 years of experience in process development and scale-up within biopharmaceutical, biotechnology, or related industries.
Demonstrated experience with microbial fermentation processes and associated bioreactor technology.
Strong understanding of downstream processing techniques (e.g., filtration, chromatography, centrifugation).
Proficiency in process modeling and simulation software relevant to bioprocesses.
Familiarity with GMP regulations and validation principles in a biopharmaceutical context.
Excellent analytical, problem-solving, and data interpretation skills.
Strong communication and teamwork abilities, with experience working in cross-functional teams.
Experience with aseptic techniques and sterile processing is advantageous.
Ability to manage multiple tasks and projects in a dynamic R&D environment.

Responsibilities

Design, operate, and optimize pilot-scale and commercial-scale fermentation processes.
Develop and validate downstream processing steps, including separation, purification, and formulation.
Conduct process characterization studies to understand critical process parameters and their impact on product quality and yield.
Perform mass and energy balances, and size equipment for bioprocess applications.
Develop and troubleshoot unit operations specific to biomanufacturing, such as bioreactors, centrifuges, filtration systems, and chromatography.
Collaborate with analytical development teams to establish appropriate testing methods and specifications.
Ensure all activities comply with Good Manufacturing Practices (GMP) and relevant regulatory guidelines.
Prepare technical reports, batch records, and process documentation for internal review and regulatory submissions.
Contribute to process transfer activities between R&D, pilot, and manufacturing sites.
Stay abreast of advancements in bioprocess engineering and related technologies.