Bioprocess Engineer - Upstream Development

Placements24; Polokwane; Ibrido; ZAR 700.000 - 900.000; Tempo pieno

Vantaggi offerti da questo lavoro

Health insurance

Retirement savings plans

Professional growth opportunities

Descrizione del lavoro

Placements24, a leading pharmaceutical recruiter, seeks a Bioprocess Engineer for upstream development in Polokwane, Limpopo, ZA. The hybrid role blends on-site cell culture work with remote responsibilities, supporting process improvement and tech transfer.

The engineer will design experiments, optimize mammalian culture, scale from bench to pilot, and ensure GMP compliance while collaborating with QA, analytics, and downstream teams.

Competenze

• Bachelor's or Master's in Biochemical Engineering, Chemical Engineering, Biotechnology or related field.
• Minimum 3 years upstream bioprocess development experience in the pharmaceutical industry.
• Hands-on mammalian cell culture and bioreactor operation.
• Knowledge of scale-up principles and GMP regulations for biologics.
• Strong analytical, problem-solving and communication skills.
• Ability to work both independently and as part of a hybrid team; remote task management.

Mansioni

• Design, execute, and analyze experiments for upstream process development including cell line characterization and media optimization.
• Optimize bioreactor operating parameters to maximize cell growth and product titer.
• Perform process scale-up from bench to pilot-scale bioreactors.
• Develop and implement robust process control strategies.
• Conduct root cause analysis for process deviations and implement corrective actions.
• Prepare detailed protocols, reports, and presentations.
• Collaborate with analytical development, downstream processing, and quality assurance teams.
• Maintain accurate records and upkeep of lab equipment.
• Ensure activities comply with GMP guidelines and safety protocols.
• Assist in regulatory documentation preparation.

Conoscenze

Cell biology

Bioreactor operation

Process engineering

Analytical thinking

Written & verbal communication

Statistical analysis

Formazione

Bachelor's or Master's degree in Biochemical Engineering

Strumenti

Statistical analysis software

Descrizione del lavoro

About the Role

Our client, a leading **Pharmaceutical** company with a strong focus on biologics, is seeking a talented **Bioprocess Engineer** to join their upstream development team. This role, based in **Polokwane, Limpopo, ZA**, will involve the development, optimization, and scale-up of mammalian cell culture processes for the production of therapeutic proteins. You will work within a state-of-the-art facility, contributing to the advancement of innovative medicines. The ideal candidate will possess a solid understanding of cell biology, bioreactor technology, and process engineering principles. This is a hybrid position, offering a blend of on-site lab work and remote responsibilities, promoting a healthy work-life balance.

Key Responsibilities

• Design, execute, and analyze experiments for upstream process development, including cell line characterization and media optimization.
• Optimize bioreactor operating parameters (e.g., temperature, pH, dissolved oxygen, feeding strategies) to maximize cell growth and product titer.
• Perform process scale-up studies from bench-scale to pilot-scale bioreactors.
• Develop and implement robust process control strategies.
• Conduct root cause analysis for process deviations and implement corrective actions.
• Prepare detailed experimental protocols, reports, and presentations.
• Collaborate effectively with analytical development, downstream processing, and quality assurance teams.
• Maintain accurate experimental records and contribute to the upkeep of lab equipment.
• Ensure all activities comply with **Pharmaceutical** GMP guidelines and safety protocols.
• Assist in the preparation of documentation for regulatory submissions.

Requirements

• Bachelor's or Master's degree in Biochemical Engineering, Chemical Engineering, Biotechnology, or a related scientific discipline.
• Minimum of 3 years of experience in upstream bioprocess development, preferably within the **Pharmaceutical** industry.
• Hands-on experience with mammalian cell culture and bioreactor operation.
• Knowledge of process scale-up principles and techniques.
• Familiarity with GMP regulations and quality requirements for biologics manufacturing.
• Strong analytical and problem-solving skills.
• Excellent written and verbal communication skills.
• Ability to work effectively both independently and as part of a hybrid team, managing tasks remotely when applicable.
• Proficiency in statistical analysis software and experimental design is a plus.

Benefits

Our client offers a competitive salary, comprehensive benefits package including health insurance and retirement savings plans, and opportunities for professional growth and development. This hybrid role in **Polokwane, Limpopo, ZA** provides a flexible work environment. Join a dedicated team focused on bringing life-changing **Pharmaceutical** products to patients.