VP, Medical Affairs

Tyra Biosciences; United States; On-site; USD 406,000 - 443,000; Full time

Benefits offered by this job

Competitive base

Equity package

401(k) plan

Paid holidays

Flexible vacation

Parental leave

Tuition assistance

Job summary

Tyra Biosciences, Inc. is seeking a highly motivated and experienced VP of Medical Affairs to lead medical strategy across oncology programs and drive impactful scientific communications.

The role requires strong leadership, cross-functional collaboration, and expertise in evidence generation, publication planning, and KOL engagement. The position offers strategic influence in a startup biopharma environment with global/regional regulatory and payer considerations, plus travel up to 20-30%

Qualifications

• 8–10+ years in pharma/biotech with global or US Medical Affairs experience.
• Experience in oncology with genitourinary/cancer focus is a plus.
• Proven track record leading medical strategies and teams in a matrixed environment.
• Strong understanding of clinical development, regulatory landscapes, and payer expectations in US/intl markets.

Responsibilities

• Develop and execute medical affairs strategies aligned with corporate objectives.
• Oversee scientific communications, medical education, KOL engagement, RWE generation, and medical insights.
• Partner with R&D and Clinical Development to shape evidence generation plans.
• Lead publication planning and high-quality dissemination across journals and conferences.
• Ensure regulatory compliance and cross-functional alignment on medical differentiation.

Skills

Medical leadership

Strategic planning

Communication skills

Cross-functional collaboration

Travel up to 30%

Education

MD, PharmD, or PhD

Job description

Position Overview

Tyra Biosciences, Inc. is seeking a highly motivated and experienced VP of Medical Affairs to make impactful contributions to multiple oncology programs targeting disease areas with high unmet medical need. The successful candidate will be highly organized, self-motivated, and thrive in a dynamic, cross functional start-up environment.

Key Responsibilities

• Strategic Leadership & Execution
• Develop and execute comprehensive medical affairs strategies aligned with corporate and commercial objectives.
• Serve as the primary medical affairs leader overseeing scientific communications, medical education, KOL engagement, real-world evidence (RWE) generation, and medical insights.
• Partner with R&D and Clinical Development teams to provide medical expertise on pipeline assets and shape evidence generation plans.
• Key Stakeholder Engagement
• Build and maintain strong relationships with Key Opinion Leaders (KOLs), healthcare professionals (HCPs), and payers to drive scientific exchange and advocacy.
• Represent the company at scientific congresses, advisory boards, and industry forums to enhance the company’s reputation as a leader in the therapeutic space.
• Provide scientific and medical leadership for investigator-initiated studies (IIS), post-marketing studies, and collaborative research initiatives.
• Medical Strategy & Communications
• Oversee the development and execution of medical education programs, advisory boards, and scientific symposia.
• Lead publication planning and execution, ensuring high-quality scientific dissemination across key medical journals and conferences.
• Guide the development of medical and commercial materials, ensuring scientific accuracy and compliance with regulatory requirements.
• Cross-functional Collaboration & Compliance
• Act as a bridge between Medical Affairs, Commercial, Market Access, and R&D teams, ensuring alignment on product positioning and medical differentiation.
• Partner with regulatory and legal teams to ensure all medical activities comply with FDA, EMA, and other global regulatory requirements.
• Provide leadership on initiatives to support value demonstration and payer engagement.
• Contribute or lead process improvement initiatives.
• Other duties as assigned.

Qualifications & Experience

• MD, PharmD, or PhD with extensive experience in Medical Affairs and Oncology
• 8 - 10+ years of experience in the pharmaceutical, biotechnology, or life sciences industry, with a strong background in global or US Medical Affairs
• Experience in genitourinary cancer, depth in bladder cancer a significant plus
• Proven track record of leading medical strategies and teams in a complex, matrixed environment.
• Strong understanding of clinical development, regulatory landscapes, and payer expectations in the US and/or major international markets.
• Experience in launch planning, scientific engagement, and evidence generation in a highly competitive therapeutic area.
• Deep expertise in medical communications, scientific publications, and external stakeholder engagement.
• Excellent leadership skills with the ability to influence cross-functional teams and drive execution.
• Direct contributions to high-impact publications, and product launches.
• Experience with the design and conduct of clinical trials and clinical operations
• Excellent communication skills, including ability to create new materials to be used for both internal and external audiences
• Demonstrated customer focus and orientation
• Evident ability to lead, create, innovate, and flex within a changing environment
• Demonstrated ability to respond and move projects forward with a sense of urgency, understanding the need for immediate communication and resolution.
• Innovative thinking and problem-solving skills, with strong analytical and strategic ability.
• Excellent written and verbal communication skills.
• Passion for working in a small, start-up biotech work environment– including being self-motivated and proactive.
• Ability to accommodate up to 20-30% travel or as business dictates.

Base Salary Range

$405,700 - $442,600 USD

Individual compensation will be determined based on factors such as work location, skills, education, training, and experience.

What We Offer US-based Employees

• Competitive base, bonus, new hire and ongoing equity packages
• The starting compensation range(s) for this role is for a full-time employee (FTE) basis
• Benefit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment
• Employer-paid Medical, dental, and vision insurance
• Employer-paid life insurance, AD&D, short-term disability, long-term disability, and EAP coverage
• 401(k) Plan with a fully vested company match 1:1 up to 4% of contributions
• Employee Stock Purchase Plan
• 14 -18 paid holidays, including office closure between December 25th and January 1st
• Flexible vacation
• Sick time
• Fitness Program
• Get Outdoors Program
• Paid parental leave benefit
• Tuition assistance

Equal Opportunity Employer

Tyra Biosciences is an equal opportunity employer committed to building a diverse and inclusive workforce. Employment decisions are made without regard to race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information, gender identity or expression, veteran status, or any other characteristic protected by applicable federal, state, or local laws.