VP, Chief Enterprise Architect

GlaxoSmithKline; Durham (NC); On-site; USD 180,000 - 240,000; Full time

Job summary

GlaxoSmithKline seeks a VP, Chief Enterprise Architect to set a vision for enterprise-wide architecture, AI-enabled transformation, and executive-level impact across our global business. This role defines target-state architecture across digital, data, AI, cloud, and core platforms to accelerate R&D, manufacturing, and commercial excellence while ensuring regulatory resilience.

You will lead governance, standards, and a federated architecture community, mentoring senior architects and partnering

Qualifications

• Advanced degree (MS, MBA, or equivalent) and relevant certifications preferred.
• Significant enterprise architecture leadership in global, regulated environments.
• Experience in bio-pharma, healthcare, or life sciences ideal.
• Demonstrated ownership of enterprise-wide digital and AI transformation strategies delivering measurable business impact.
• Experience architecting scalable AI, cloud, data platforms in regulated industries.
• Proven ability to influence executive stakeholders and translate complex strategies into business-aligned action.
• Strong execution discipline - balancing strategic vision with practical delivery.
• Demonstrated success reducing enterprise complexity, rationalizing legacy estates, and accelerating platform adoption.
• Thought leadership through industry forums, publishing, or standards bodies.
• Experience integrating architecture strategies post-M&A and during operating model transformation.
• Proven ability to mentor senior architects and build federated global architecture communities.

Responsibilities

• Define and lead a multi-year enterprise architecture strategy aligned to business growth, AI scale, operational excellence, and regulatory requirements.
• Establish a clear target-state architecture and phased transformation roadmap across global business units.
• Ensure technology investments reduce complexity, enable reuse, and accelerate innovation velocity.
• Design the enterprise AI and data platform architecture to enable AI-at-scale across R&D, manufacturing, and commercial functions.
• Establish standards for responsible AI, model governance, data interoperability, and secure AI deployment in regulated environments.
• Accelerate AI solution deployment through reusable patterns, reference architectures, and scalable digital platforms.
• Advise senior business and technology leaders, translating complex enterprise challenges into actionable architecture roadmaps tied to measurable outcomes.
• Align architecture priorities to business KPIs such as time-to-market, productivity gains, cost optimization, and risk reduction.
• Serve as enterprise design authority for major transformation programs and strategic investments.
• Design pragmatic, agile architecture governance that balances innovation with security, compliance, and enterprise risk management.
• Lead enterprise standards across cloud, data, integration, security, and AI domains.
• Guide architecture strategy during M&A, integration, and organizational redesign efforts.
• Build, inspire, and scale a high-performing global architecture community across enterprise, domain, data, AI, and platform disciplines.
• Champion architecture as a strategic capability - shifting from review-and-approve to enable-and-accelerate.
• Foster a culture of learning, experimentation, and disciplined execution.
• Cultivate strong partnerships across global business functions, external innovators, and strategic technology partners.
• Represent enterprise architecture in executive forums and strategic planning discussions.

Skills

Automation Technology

Cloud Based Services

Computer Programming

Configuration Management (CM)

Container Orchestration

Database Management

Enterprise Backups

Infrastructure Security

Network Services

Operating Systems (OS)

Scripting

Service Integration

System Monitors

Troubleshooting

Education

Advanced degree (MS, MBA, or equivalent)

TOGAF or advanced cloud/AI architecture certifications

Job description

As the VP, Chief Enterprise Architect, you will set the vision for enterprise-wide architecture-driving digital and AI-enabled transformation, and influencing business strategy at the highest levels. You'll bring consultative leadership, deep technical expertise, and executive presence to orchestrate change and deliver lasting impact across our global business.

In this role, you will set the target-state architecture across digital, data, AI, cloud, and core platforms. You will ensure our technology landscape accelerates R&D innovation, modernizes manufacturing, enhances commercial effectiveness, and strengthens regulatory resilience. This is a strategic executive leadership role requiring consultative influence, technical depth, and the ability to translate emerging technologies into scalable, secure, and AI-ready enterprise capabilities across a highly regulated global organization.

Key Responsibilities

Vision & Enterprise Strategy

• Define and lead a multi-year enterprise architecture strategy aligned to business growth, AI scale, operational excellence, and regulatory requirements.
• Establish a clear target-state architecture and phased transformation roadmap across global business units.
• Ensure technology investments reduce complexity, enable reuse, and accelerate innovation velocity.

Enterprise AI & Platform Enablement

• Design the enterprise AI and data platform architecture to enable AI-at-scale across R&D, manufacturing, and commercial functions.
• Establish standards for responsible AI, model governance, data interoperability, and secure AI deployment in regulated environments.
• Accelerate AI solution deployment through reusable patterns, reference architectures, and scalable digital platforms.

Executive Influence & Business Partnership

• Advise senior business and technology leaders, translating complex enterprise challenges into actionable architecture roadmaps tied to measurable outcomes.
• Align architecture priorities to business KPIs such as time-to-market, productivity gains, cost optimization, and risk reduction.
• Serve as enterprise design authority for major transformation programs and strategic investments.

Governance & Risk

• Design pragmatic, agile architecture governance that balances innovation with security, compliance, and enterprise risk management.
• Lead enterprise standards across cloud, data, integration, security, and AI domains.
• Guide architecture strategy during M&A, integration, and organizational redesign efforts.

Organizational Leadership & Evangelism

• Build, inspire, and scale a high-performing global architecture community across enterprise, domain, data, AI, and platform disciplines.
• Champion architecture as a strategic capability - shifting from review-and-approve to enable-and-accelerate.
• Foster a culture of learning, experimentation, and disciplined execution.

Stakeholder Engagement

• Cultivate strong partnerships across global business functions, external innovators, and strategic technology partners.
• Represent enterprise architecture in executive forums and strategic planning discussions.

Why You?

We are seeking professionals with the following skills and qualifications to help us achieve our goals:

• Advanced degree (MS, MBA, or equivalent) and relevant certifications (TOGAF, advanced cloud or AI architecture credentials) would be preferred.
• Significant enterprise architecture leadership experience, including service as Chief Architect or Enterprise Architecture VP within a complex, global organizations.
• Experience in global, highly regulated environments such as bio-pharma, healthcare, or life sciences would be ideal.
• Demonstrated ownership of enterprise-wide digital and AI transformation strategies delivering measurable business impact.
• Experience architecting scalable AI, cloud, data, and platform ecosystems in regulated industries.
• Proven ability to influence executive stakeholders and simplify complex technical strategies into business-aligned action.
• Strong execution discipline - balancing strategic vision with practical delivery.
• Demonstrated success reducing enterprise complexity, rationalizing legacy estates, and accelerating platform adoption.
• Thought leadership through industry forums, publishing, or standards bodies.
• Experience integrating architecture strategies post-M&A and during large-scale operating model transformation.
• Proven ability to mentor senior architects and build federated global architecture communities.

Skills

Automation Technology, Cloud Based Services, Computer Programming, Configuration Management (CM), Container Orchestration, Database Management, Enterprise Backups, Infrastructure Security, Network Services, Operating Systems (OS), Scripting, Service Integration, System Monitors, Troubleshooting

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases - to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we're committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

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