Vice President / Senior Vice President, Clinical Development (AID)

Janux Therapeutics, Inc.; San Diego (CA); On-site; USD 350,000 - 450,000; Full time

Benefits offered by this job

Stock options

Restricted stock units

Stock purchase plan (ESPP)

Annual bonus program

Comprehensive medical insurance

Relocation assistance

HSA, FSA, disability insurance

Unlimited PTO

Generous holiday schedule

Job summary

Janux Therapeutics, Inc. seeks a VP/SVP, Clinical Development to lead the strategic vision for its autoimmune pipeline and shape the company’s entry into autoimmune diseases.

Reporting to the CEO, you will steer portfolio leadership, partner with internal and external stakeholders, and ensure clinical integrity via medical monitoring oversight across programs.

Qualifications

• MD or DO with subspecialty in immunology or autoimmune diseases.
• Senior clinical leader with success in large pharma/biotech.
• Proven strategic leadership in clinical development and portfolio management.
• Innovative, entrepreneurial mindset with change leadership.
• Deep understanding of early drug development and regulatory requirements.

Responsibilities

• Set and execute strategic vision for autoimmune development aligned with goals.
• Lead cross-functional teams on strategy, differentiation, and speed to market.
• Oversee program execution and delegate day‑to‑day monitoring activities.
• Ensure patient safety and clinical integrity through medical monitoring oversight.
• Advise on trial design, regulatory strategy, and data interpretation.
• Serve as primary medical/scientific spokesperson for immunology franchise.
• Cultivate relationships with key opinion leaders and external partners.
• Drive growth, talent development, and succession planning in clinical development.
• Other duties as deemed essential.

Skills

Leadership

Strategic vision

Stakeholder management

Communication

Education

MD or DO with subspecialty in immunology

Senior clinical leader in pharma/biotech

Clinical development and portfolio leadership

Early drug development and regulatory knowledge

Job description

The Vice President/Senior Vice President, Clinical Development will serve as the strategic clinical leader for Janux’s expanding autoimmune pipeline, driving the vision and execution of clinical development programs in autoimmune diseases. This leader, reporting to the CEO, will shape the company’s entry into autoimmune diseases, leveraging a differentiated platform to address significant unmet needs. The VP/SVP will be responsible for high-level strategy, portfolio leadership, and thought partnership with internal and external stakeholders, while ensuring clinical integrity through oversight of medical monitoring.

ESSENTIAL FUNCTIONS AND RESPONSIBILITIES:

• Set and execute the strategic vision for clinical development in autoimmune diseases, ensuring alignment with corporate goals and maximizing portfolio value.
• Lead cross-functional teams in the design and implementation of clinical development strategies, focusing on innovation, differentiation, and speed to market.
• Oversee clinical program execution at a strategic level, delegating operational and hands‑on responsibilities to clinical teams and direct reports.
• Maintain ultimate accountability for medical monitoring, ensuring patient safety and clinical integrity, but delegate day‑to‑day monitoring activities to appropriate team members.
• Provide expert guidance and strategic input on clinical trial design, regulatory strategy, and data interpretation.
• Serve as the primary medical and scientific spokesperson for the immunology franchise, internally and externally.
• Cultivate relationships with key opinion leaders, investigators, and external partners to advance Janux’s immunology pipeline.
• Drive organizational growth, talent development, and succession planning within the clinical development function.
• Other duties as deemed essential

EDUCATION, EXPERIENCE, KNOWLEDGE, SKILLS AND ABILITIES

• MD or DO with subspecialty in immunology, autoimmune diseases, or related fields.
• Demonstrated success as a senior clinical leader (e.g., therapeutic area head, franchise lead) in large pharma or biotech, with broad immunology experience.
• Proven track record of strategic leadership in clinical development, portfolio management, and cross-functional team building.
• Innovative, entrepreneurial mindset; experience driving change and building new capabilities.
• Deep understanding of early drug development, clinical trial processes, and regulatory requirements in immunology/inflammation.
• Exceptional communication, influence, and stakeholder management skills.
• Strong ability to critically evaluate data, literature, and presentations.
• High level of communication skills is expected.

$350,000 - $450,000 a year

In addition to a competitive base salary ranging from $350,000 to $450,000, we offer stock options, restricted stock units, a stock purchase plan (ESPP) and a target bonus. Janux also provides a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, and supplemental disability insurance. Relocation assistance may also be available.

Please note that the base salary range is a guideline, and individual total compensation will vary based on factors such as qualifications, skill level, competencies, and internal equity.

Job Type

Full-time

Benefits

• Annual bonus program
• Incentive stock option plan
• 401k plan with flat non-elective employer contribution
• Comprehensive medical insurance with 90-100% employer-paid premiums
• Dental and vision insurance
• HSA, FSA, and supplemental insurance plans (life, disability, accident, critical illness, hospital indemnity)
• Unlimited PTO
• Generous holiday schedule; includes summer and winter company shutdown
• Relocation assistance

Schedule

• Monday to Friday

Work authorization

• United States (Required)

Additional Compensation

• Annual targeted bonus %

Work Location

• Hybrid preferred in San Diego office. Remote permitted upon approval, with ability to travel up to 25% for meetings or site visits as required.

EQUAL OPPORTUNITY EMPLOYER

Janux Therapeutics, Inc. is an equal opportunity employer that is committed to providing a work environment free of harassment and discrimination based upon a protected category, as well as an environment free from retaliation for protected activity.